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Sickle haemoglobin, haemoglobin C and malaria mortality feedbacks
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Gonçalves, Bronner P., Gupta, Sunetra and Penman, Bridget S. (2016) Sickle haemoglobin, haemoglobin C and malaria mortality feedbacks. Malaria Journal, 15 (1). pp. 1-7. 26. doi:10.1186/s12936-015-1077-5
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Official URL: http://dx.doi.org/10.1186/s12936-015-1077-5
Abstract
Sickle haemoglobin (HbS) and haemoglobin C (HbC) are both caused by point mutations in the beta globin gene, and both offer substantial malaria protection. Despite the fact that the blood disorder caused by homozygosity for HbC is much less severe than that caused by homozygosity for HbS (sickle cell anaemia), it is the sickle mutation which has come to dominate many old-world malarious regions, whilst HbC is highly restricted in its geographical distribution. It has been suggested that this discrepancy may be due to sickle cell heterozygotes enjoying a higher level of malaria protection than heterozygotes for HbC. A higher fitness of sickle cell heterozygotes relative to HbC heterozygotes could certainly have allowed the sickle cell allele to spread more rapidly. However, observations that carrying either HbC or HbS enhances an individual’s capacity to transmit malaria parasites to mosquitoes could also shed light on this conundrum.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Journal or Publication Title: | Malaria Journal | ||||||||
| Publisher: | BioMed Central Ltd. | ||||||||
| ISSN: | 1475-2875 | ||||||||
| Official Date: | 12 January 2016 | ||||||||
| Dates: |
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| Volume: | 15 | ||||||||
| Number: | 1 | ||||||||
| Number of Pages: | 7 | ||||||||
| Page Range: | pp. 1-7 | ||||||||
| Article Number: | 26 | ||||||||
| DOI: | 10.1186/s12936-015-1077-5 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
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