Levin, Bruce R., Watkins, Eleanor R., Penman, Bridget S., Lourenço, José, Buckee, Caroline O., Maiden, Martin C. J. and Gupta, Sunetra (2015) Vaccination drives changes in metabolic and virulence profiles of Streptococcus pneumoniae. PLoS Pathogens, 11 (7). e1005034. doi:10.1371/journal.ppat.1005034

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Abstract

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.

Item Type:	Journal Article
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	PLoS Pathogens
Publisher:	Public Library of Science
ISSN:	1553-7374
Official Date:	16 July 2015
Dates:	Date Event 16 July 2015 Published 19 June 2015 Accepted 13 January 2015 Submitted
Volume:	11
Number:	7
Article Number:	e1005034
DOI:	10.1371/journal.ppat.1005034
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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