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Vaccination drives changes in metabolic and virulence profiles of Streptococcus pneumoniae
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Levin, Bruce R., Watkins, Eleanor R., Penman, Bridget S., Lourenço, José, Buckee, Caroline O., Maiden, Martin C. J. and Gupta, Sunetra (2015) Vaccination drives changes in metabolic and virulence profiles of Streptococcus pneumoniae. PLoS Pathogens, 11 (7). e1005034. doi:10.1371/journal.ppat.1005034 ISSN 1553-7374.
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Official URL: http://dx.doi.org/10.1371/journal.ppat.1005034
Abstract
The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Journal or Publication Title: | PLoS Pathogens | ||||||||
Publisher: | Public Library of Science | ||||||||
ISSN: | 1553-7374 | ||||||||
Official Date: | 16 July 2015 | ||||||||
Dates: |
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Volume: | 11 | ||||||||
Number: | 7 | ||||||||
Article Number: | e1005034 | ||||||||
DOI: | 10.1371/journal.ppat.1005034 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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