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Pathogen selection drives nonoverlapping associations between HLA loci
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Penman, Bridget S., Ashby, B., Buckee, C. O. and Gupta, S. (2013) Pathogen selection drives nonoverlapping associations between HLA loci. Proceedings of the National Academy of Sciences of the United States of America, 110 (48). pp. 19645-19650. doi:10.1073/pnas.1304218110
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Official URL: http://dx.doi.org/10.1073/pnas.1304218110
Abstract
Human leukocyte antigens (HLA), first identified in tissue-matching for transplantation, play a critical role in immunity. HLAs are extraordinarily diverse, but certain sets of HLA genes are more likely to be found together than others. Here, we show that associations between HLA genes can arise through their coevolutionary interaction with pathogens. Technological advances are making it easier to determine HLA types, but DNA sequence alone cannot fully predict an HLA’s functional properties. Our work offers a new evolutionary approach to tackling this problem.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | Proceedings of the National Academy of Sciences of the United States of America | ||||||
| Publisher: | National Academy of Sciences | ||||||
| ISSN: | 0027-8424 | ||||||
| Official Date: | 2013 | ||||||
| Dates: |
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| Volume: | 110 | ||||||
| Number: | 48 | ||||||
| Page Range: | pp. 19645-19650 | ||||||
| DOI: | 10.1073/pnas.1304218110 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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