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Pathogen selection drives nonoverlapping associations between HLA loci

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Penman, Bridget S., Ashby, B., Buckee, C. O. and Gupta, S. (2013) Pathogen selection drives nonoverlapping associations between HLA loci. Proceedings of the National Academy of Sciences of the United States of America, 110 (48). pp. 19645-19650. doi:10.1073/pnas.1304218110

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Official URL: http://dx.doi.org/10.1073/pnas.1304218110

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Abstract

Human leukocyte antigens (HLA), first identified in tissue-matching for transplantation, play a critical role in immunity. HLAs are extraordinarily diverse, but certain sets of HLA genes are more likely to be found together than others. Here, we show that associations between HLA genes can arise through their coevolutionary interaction with pathogens. Technological advances are making it easier to determine HLA types, but DNA sequence alone cannot fully predict an HLA’s functional properties. Our work offers a new evolutionary approach to tackling this problem.

Item Type: Journal Article
Divisions: Faculty of Science > Life Sciences (2010- )
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Publisher: National Academy of Sciences
ISSN: 0027-8424
Official Date: 2013
Dates:
DateEvent
2013Published
14 October 2013Accepted
Volume: 110
Number: 48
Page Range: pp. 19645-19650
DOI: 10.1073/pnas.1304218110
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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