Baltatzis, Minas, Mason, James, Chandrabalan, Vishnu, Stathakis, Panagiotis, McIntyre, Ben, Jegatheeswaran, Santhalingam, Jamdar, Saurabh, O'Reilly, Derek A. and Siriwardena, Ajith K. (2016) Antibiotic use in acute pancreatitis : an audit of current practice in a tertiary centre. Pancreatology, 16 (6). pp. 946-951. doi:10.1016/j.pan.2016.08.012 ISSN 1424-3911.

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Abstract

Introduction:
Intravenous antibiotic prophylaxis is not recommended in acute pancreatitis. According to current international guidelines antibiotics together with further intervention should be considered in the setting of infected necrosis. Appropriate antibiotic therapy particularly avoiding over-prescription is important. This study examines antibiotic use in acute pancreatitis in a tertiary centre using the current IAP/APA guidelines for reference.

Methods:
Data were collected on a consecutive series of patients admitted with acute pancreatitis over a 12 month period. Data were dichotomized by patients admitted directly to the centre and tertiary transfers. Information was collected on clinical course with specific reference to antibiotic use, episode severity, intervention and outcome.

Results:
111 consecutive episodes of acute pancreatitis constitute the reported population. 31 (28%) were tertiary transfers. Overall 65 (58.5%) patients received antibiotics. Significantly more tertiary transfer patients received antibiotics. Mean person-days of antibiotic use was 23.9 (sd 29.7) days in the overall study group but there was significantly more use in the tertiary transfer group as compared to patients having their index admission to the centre (40.9 sd 37.1 vs 10.2 sd 8.9; P < 0.005). Thirty four (44%) of patients with clinically mild acute pancreatitis received antibiotics.

Conclusions:
There is substantial use of antibiotics in acute pancreatitis, in particular in patients with severe disease. Over-use is seen in mild acute pancreatitis. Better consideration must be given to identification of prophylaxis or therapy as indication. In relation to repeated courses of antibiotics in severe disease there must be clear indications for use.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Pancreatitis -- Treatment, Pancreas -- Diseases , Antibiotics, American Pancreatic Association
Journal or Publication Title:	Pancreatology
Publisher:	Elsevier BV
ISSN:	1424-3911
Official Date:	November 2016
Dates:	Date Event November 2016 Published 30 August 2016 Available 29 August 2016 Accepted 17 June 2016 Submitted
Volume:	16
Number:	6
Page Range:	pp. 946-951
DOI:	10.1016/j.pan.2016.08.012
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Date of first compliant deposit:	22 September 2016
Date of first compliant Open Access:	30 August 2017

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