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CYP3A5 as a candidate gene for hypertension : no support from an unselected indigenous West African population
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Fisher, D. L., Plange-Rhule, J., Moreton, M., Eastwood, J. B., Kerry, S. M., Micah, F., Johnston, A., Cappuccio, Francesco and MacPhee, I. A. M. (2016) CYP3A5 as a candidate gene for hypertension : no support from an unselected indigenous West African population. Journal of Human Hypertension, 30 (12). pp. 778-782. doi:10.1038/jhh.2016.25 ISSN 0950-9240.
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Official URL: http://dx.doi.org/10.1038/jhh.2016.25
Abstract
CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) expression stimulates the sodium retentive actions of the mineralocorticoid receptor causative of hypertension, probably by means of its ability to substantially increase the level of 6β-hydroxylase activity. Most Black individuals are functional CYP3A5 expressers, and this is a candidate gene for the high incidence of hypertension in Black populations. The study investigates whether CYP3A5 expression results in higher blood pressure in a Ghanaian population. Real-time PCR was used to genotype 898 DNA samples for the CYP3A5*3 and CYP3A5*6 single-nucleotide polymorphisms with technically adequate genotyping for 881 samples. Of these, 803 were genetic CYP3A5 expressers, 44 nonexpressers and 34 uncertain (CYP3A5*3/*6). Although there was a trend in the proportion of hypertensive individuals as CYP3A5 expression decreased, using a two-sided t-test, no statistically significant relationship was established between systolic or diastolic pressure and CYP3A5*3 or CYP3A5*6 genotypes, or their haplotypes (Systolic confidence interval: −8.44 to –7.70, P=0.93, Diastolic confidence interval: −4.89 to 4.85, P=0.99). We conclude, therefore, that there is either no association between CYP3A5 expression and blood pressure or, if there is a relationship, the strength of the association is very small.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Journal of Human Hypertension | ||||||
Publisher: | Nature Publishing Group | ||||||
ISSN: | 0950-9240 | ||||||
Official Date: | 23 June 2016 | ||||||
Dates: |
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Volume: | 30 | ||||||
Number: | 12 | ||||||
Page Range: | pp. 778-782 | ||||||
DOI: | 10.1038/jhh.2016.25 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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