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Glycosphingolipids as toxin receptors
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UNSPECIFIED (2004) Glycosphingolipids as toxin receptors. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 15 (4). pp. 397-408. ISSN 1084-9521
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Official URL: http://dx.doi.org/10.1016/j.semedb.2004.03.005
Abstract
A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis. To reach their targets, these proteins bind specific surface receptors before endocytosis and translocation across an internal membrane. The surface receptors exploited by different toxins include a range of proteins and lipids. Here we focus on specific glycosphingolipid receptors and two well-characterised subsets of toxins that exploit them for surface binding, intracellular trafficking, and signalling events. (C) 2004 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Item |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY |
| Publisher: | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD |
| ISSN: | 1084-9521 |
| Date: | August 2004 |
| Volume: | 15 |
| Number: | 4 |
| Number of Pages: | 12 |
| Page Range: | pp. 397-408 |
| Identification Number: | 10.1016/j.semedb.2004.03.005 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/8210 |
Data sourced from Thomson Reuters' Web of Knowledge
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