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Functional near infrared spectroscopy as a probe of brain function in people with prolonged disorders of consciousness
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Kempny, Agnieszka M., James, Leon, Yelden, Kudret, Duport, Sophie, Farmer, Simon, Playford, E. Diane and Leff, Alexander P. (2016) Functional near infrared spectroscopy as a probe of brain function in people with prolonged disorders of consciousness. NeuroImage: Clinical, 12 . pp. 312-319. doi:10.1016/j.nicl.2016.07.013 ISSN 2213-1582.
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Official URL: http://dx.doi.org/10.1016/j.nicl.2016.07.013
Abstract
Near infrared spectroscopy (NIRS) is a non-invasive technique which measures changes in brain tissue oxygenation. NIRS has been used for continuous monitoring of brain oxygenation during medical procedures carrying high risk of iatrogenic brain ischemia and also has been adopted by cognitive neuroscience for studies on executive and cognitive functions. Until now, NIRS has not been used to detect residual cognitive functions in patients with prolonged disorders of consciousness (pDOC). In this study we aimed to evaluate the brain function of patients with pDOC by using a motor imagery task while recording NIRS. We also collected data from a group of age and gender matched healthy controls while they carried out both real and imagined motor movements to command. We studied 16 pDOC patients in total, split into two groups: five had a diagnosis of Vegetative state/Unresponsive Wakefulness State, and eleven had a diagnosis of Minimally Conscious State. In the control subjects we found a greater oxy-haemoglobin (oxyHb) response during real movement compared with imagined movement. For the between group comparison, we found a main effect of hemisphere, with greater depression of oxyHb signal in the right > left hemisphere compared with rest period for all three groups. A post-hoc analysis including only the two pDOC patient groups was also significant suggesting that this effect was not just being driven by the control subjects. This study demonstrates for the first time the feasibility of using NIRS for the assessment of brain function in pDOC patients using a motor imagery task.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| Library of Congress Subject Headings (LCSH): | Near infrared spectroscopy, Persistent vegetative state , Brain damage | ||||||||
| Journal or Publication Title: | NeuroImage: Clinical | ||||||||
| Publisher: | Elsevier BV | ||||||||
| ISSN: | 2213-1582 | ||||||||
| Official Date: | 27 July 2016 | ||||||||
| Dates: |
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| Volume: | 12 | ||||||||
| Page Range: | pp. 312-319 | ||||||||
| DOI: | 10.1016/j.nicl.2016.07.013 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 17 October 2016 | ||||||||
| Date of first compliant Open Access: | 18 October 2016 | ||||||||
| Funder: | Royal Hospital for Neuro-disability, University College London Hospitals. Biomedical Research Centre (UCLHBRC) | ||||||||
| Adapted As: |
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