Defining poor ovarian response during IVF cycles, in women aged < 40 years, and its relationship with treatment outcome
UNSPECIFIED. (2004) Defining poor ovarian response during IVF cycles, in women aged < 40 years, and its relationship with treatment outcome. HUMAN REPRODUCTION, 19 (7). pp. 1544-1547. ISSN 0268-1161Full text not available from this repository.
Official URL: http://dx.doi.org/10.1093/humrep/deh273
BACKGROUND: Poor ovarian response limits IVF success but assessing interventions is difficult because of the wide variation in definition. This study attempts to derive objective definitions of poor response. METHODS: A retrospective study of a consecutive series of 1190 patients aged <40 years undergoing their first IVF/ICSI cycle was undertaken. Factors adversely affecting implantation, including advanced female age, were excluded. Clinical outcome in cycles reaching oocyte retrieval (n = 1036) were evaluated with respect to gonadotrophin dose used and oocyte number. Cancelled cycles (n = 154) were analysed in relation to the stimulation dose at cancellation and outcome of their subsequent cycle. RESULTS: Cycle cancellation for patients on greater than or equal to300 IU FSH/day compared to those on a lower dose was associated with a significantly worse outcome in the subsequent cycle. If <3000 IU FSH/cycle were administered, clinical pregnancy rates remained favourable if <4 eggs were recovered (29 versus 33% for greater than or equal to5 eggs). By contrast, if greater than or equal to3000 IU FSH was required, the pregnancy rate was 25% if greater than or equal to5 eggs were recovered but declined to 7% if <4 were obtained. CONCLUSIONS: Definitions of poor response should include the degree of ovarian stimulation used. A low oocyte number is only detrimental if the cumulative dose is >3000 IU FSH. Cancellation at greater than or equal to300 IU FSH/day is associated with a significantly worse prognosis and could define poor response.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RG Gynecology and obstetrics|
|Journal or Publication Title:||HUMAN REPRODUCTION|
|Publisher:||OXFORD UNIV PRESS|
|Official Date:||July 2004|
|Number of Pages:||4|
|Page Range:||pp. 1544-1547|
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