The Library
Giant polymersome protocells dock with virus particle mimics via multivalent glycan-lectin interactions
Tools
Tools
Tools
Kubilis, Artur, Abdulkarim, Ali, Eissa, Ahmed M. and Cameron, Neil R. (2016) Giant polymersome protocells dock with virus particle mimics via multivalent glycan-lectin interactions. Scientific Reports, 6 . 32414. doi:10.1038/srep32414
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP_srep32414.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1253Kb) |
Official URL: http://dx.doi.org/10.1038/srep32414
Abstract
Despite the low complexity of their components, several simple physical systems, including microspheres, coacervate droplets and phospholipid membrane structures (liposomes), have been suggested as protocell models. These, however, lack key cellular characteristics, such as the ability to replicate or to dock with extracellular species. Here, we report a simple method for the de novo creation of synthetic cell mimics in the form of giant polymeric vesicles (polymersomes), which are capable of behavior approaching that of living cells. These polymersomes form by self-assembly, under electroformation conditions, of amphiphilic, glycosylated block copolymers in aqueous solution. The glycosylated exterior of the resulting polymeric giant unilamellar vesicles (GUVs) allows their selective interaction with carbohydrate-binding receptor-functionalized particles, in a manner reminiscent of the cell-surface docking of virus particles. We believe that this is the first example of a simple protocell model displaying cell-like behavior through a native receptor-ligand interaction.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history |
||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
| Library of Congress Subject Headings (LCSH): | Microspheres, Bilayer lipid membranes, Cells, Polymer solutions | ||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 2045-2322 | ||||||||
| Official Date: | 31 August 2016 | ||||||||
| Dates: |
|
||||||||
| Volume: | 6 | ||||||||
| Article Number: | 32414 | ||||||||
| DOI: | 10.1038/srep32414 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Leverhulme Trust (LT) | ||||||||
| Grant number: | Grant number F/00128/BO | ||||||||
| Adapted As: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
