Zhang, Qiang, Nurumbetov, Gabit, Simula, Alexandre, Zhu, Chongyu, Li, Muxiu, Wilson, Paul, Kempe, Kristian, Yang, Bin, tao, lei and Haddleton, David M. (2016) Synthesis of well-defined catechol polymers for surface functionalization of magnetic nanoparticles. Polymer Chemistry, 7 (45). 7002-7010 . doi:10.1039/c6py01709f ISSN 1759-9954.

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Abstract

In order to obtain dual-modal fluorescent magnetic nanoparticles, well-defined fluorescent functional polymers with terminal catechol groups were synthesized by single electron transfer living radical polymerization (SET-LRP) under aqueous conditions for “grafting to” modification of iron oxide nanoparticles. Acrylamide, N-isopropylacrylamide, poly(ethylene glycol) methyl ether acrylate, 2-hydroxyethyl acrylate, glycomonomer and rhodamine B piperazine acrylamide were homo-polymerized or block-copolymerized directly from an unprotected dopamine-functionalized initiator in an ice-water bath. The Cu-LRP tolerated the presence of catechol groups leading to polymers with narrow molecular weight distributions (Mw/Mn < 1.2) and high or full conversion obtained in a few minutes. Subsequent immobilization of dopamine-terminal copolymers on an iron oxide surface were successful as demonstrated by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), transition electron microscopy (TEM) and thermogravimetric analysis (TGA), generating stable polymer-coated fluorescent magnetic nanoparticles. The nanoparticles coated with hydrophilic polymers showed no significant cytotoxicity when compared with unmodified particles and the cellular-uptake of fluorescent nanoparticles by A549 cells was very efficient, which also indicated the potential application of these advanced nano materials for bio-imaging.

Item Type:	Journal Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Nanoparticles, Polymers, Catechol
Journal or Publication Title:	Polymer Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1759-9954
Official Date:	7 December 2016
Dates:	Date Event 7 December 2016 Published 28 October 2016 Available 23 October 2016 Accepted
Volume:	7
Number:	45
Page Range:	7002-7010
DOI:	10.1039/c6py01709f
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	28 October 2016
Date of first compliant Open Access:	28 October 2017
Funder:	University of Warwick, China Scholarship Council (CSC), Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA)

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