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Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry

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Foo, Mathias, Sawlekar, Rucha and Bates, Declan (2016) Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry. Journal of Biological Engineering, 10 (15).

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Official URL: http://dx.doi.org/10.1186/s13036-016-0036-1

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Abstract

Background: Cycles of covalent modification are ubiquitous motifs in cellular signalling. Although such signalling cycles are implemented via a highly concise set of chemical reactions, they have been shown to be capable of producing multiple distinct input-output mapping behaviours – ultrasensitive, hyperbolic, signal-transducing and threshold-hyperbolic. Results: In this paper, we show how the set of chemical reactions underlying covalent modification cycles can be exploited for the design of synthetic analog biomolecular circuitry. We show that biomolecular circuits based on the dynamics of covalent modification cycles allow (a) the computation of nonlinear operators using far fewer chemical reactions than purely abstract designs based on chemical reaction network theory, and (b) the design of nonlinear feedback controllers with strong performance and robustness properties. Conclusions: Our designs provide a more efficient route for translation of complex circuits and systems from chemical reactions to DNA strand displacement-based chemistry, thus facilitating their experimental implementation in future Synthetic Biology applications.

Item Type: Journal Article
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Bioengineering, Synthetic biology, Biological control systems, Systems biology, Chemical reactions
Journal or Publication Title: Journal of Biological Engineering
Publisher: BioMed Central Ltd.
ISSN: 1754-1611
Official Date: 14 October 2016
Dates:
DateEvent
14 October 2016Published
19 October 2016Accepted
Volume: 10
Number: 15
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC)
Grant number: BB/M017982/1
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