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Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry
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Foo, Mathias, Sawlekar, Rucha and Bates, Declan (2016) Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry. Journal of Biological Engineering, 10 (15).
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WRAP_1473578-engineering-021116-mf_rs_dgb_jbe_2016.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1108Kb) |
Official URL: http://dx.doi.org/10.1186/s13036-016-0036-1
Abstract
Background: Cycles of covalent modification are ubiquitous motifs in cellular signalling. Although such signalling cycles are implemented via a highly concise set of chemical reactions, they have been shown to be capable of producing multiple distinct input-output mapping behaviours – ultrasensitive, hyperbolic, signal-transducing and threshold-hyperbolic. Results: In this paper, we show how the set of chemical reactions underlying covalent modification cycles can be exploited for the design of synthetic analog biomolecular circuitry. We show that biomolecular circuits based on the dynamics of covalent modification cycles allow (a) the computation of nonlinear operators using far fewer chemical reactions than purely abstract designs based on chemical reaction network theory, and (b) the design of nonlinear feedback controllers with strong performance and robustness properties. Conclusions: Our designs provide a more efficient route for translation of complex circuits and systems from chemical reactions to DNA strand displacement-based chemistry, thus facilitating their experimental implementation in future Synthetic Biology applications.
| Item Type: | Journal Article | ||||||
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| Subjects: | T Technology > TA Engineering (General). Civil engineering (General) | ||||||
| Divisions: | Faculty of Science > Engineering | ||||||
| Library of Congress Subject Headings (LCSH): | Bioengineering, Synthetic biology, Biological control systems, Systems biology, Chemical reactions | ||||||
| Journal or Publication Title: | Journal of Biological Engineering | ||||||
| Publisher: | BioMed Central Ltd. | ||||||
| ISSN: | 1754-1611 | ||||||
| Official Date: | 14 October 2016 | ||||||
| Dates: |
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| Date of first compliant deposit: | 3 November 2016 | ||||||
| Volume: | 10 | ||||||
| Number: | 15 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) | ||||||
| Grant number: | BB/M017982/1 | ||||||
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