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The impact of cognitive training on cerebral white matter in community-dwelling elderly : one-year prospective longitudinal diffusion tensor imaging study
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Cao, Xinyi, Yao, Ye, Li, Ting, Cheng, Yan, Feng, Wei, Shen, Yuan, Li, Qingwei, Jiang, Lijuan, Wu, Wenyuan, Wang, Jijun, Sheng, Jianhua, Feng, Jianfeng and Li, Chunbo (2016) The impact of cognitive training on cerebral white matter in community-dwelling elderly : one-year prospective longitudinal diffusion tensor imaging study. Scientific Reports, 6 . 33212 . doi:10.1038/srep33212
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Official URL: http://doi.org/10.1038/srep33212
Abstract
It has been shown that cognitive training (CogTr) is effective and recuperative for older adults, and can be used to fight against cognitive decline. In this study, we investigated whether behavioural gains from CogTr would extend to white matter (WM) microstructure, and whether training-induced changes in WM integrity would be associated with improvements in cognitive function, using diffusion tensor imaging (DTI). 48 healthy community elderly were either assigned to multi-domain or single-domain CogTr groups to receive 24 sessions over 12 weeks, or to a control group. DTI was performed at both baseline and 12-month follow-up. Positive effects of multi-domain CogTr on long-term changes in DTI indices were found in posterior parietal WM. Participants in the multi-domain group showed a trend of long-term decrease in axial diffusivity (AD) without significant change in fractional anisotropy (FA), mean diffusivity (MD) or radial diffusivity (RD), while those in the control group displayed a significant FA decrease, and an increase in MD and RD. In addition, significant relationships between an improvement in processing speed and changes in RD, MD and AD were found in the multi-domain group. These findings support the hypothesis that plasticity of WM can be modified by CogTr, even in late adulthood.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||||
| Divisions: | Faculty of Science > Computer Science | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Dementia -- Prevention -- Shanghai (China), Memory -- Age factors, Older people -- Quality of Life, Diffusion tensor imaging, Neuroscience -- Research | ||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 2045-2322 | ||||||||
| Official Date: | 15 September 2016 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 28 February 2017 | ||||||||
| Volume: | 6 | ||||||||
| Article Number: | 33212 | ||||||||
| DOI: | 10.1038/srep33212 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Shanghai Shi ke xue ji shu wei yuan hui [Shanghai Science and Technology Commission] (SSTC), SHSMU-ION Research Center for Brain Disorders, Shanghai Shi jing shen wei sheng zhong xin [Shanghai Mental Health Center] (SMHC) | ||||||||
| Grant number: | 81371505, 30770769 (NSFC), 134119a2501, 13dz2260500 (SSTC), 2013-YJ-09, 2014-YJ-05 (SHSMU-ION), (SMHC) |
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