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Folding and form : insights from lattice simulations
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Faisca, P. F. N., Telo da Gama, M. M. and Ball, Robin (2004) Folding and form : insights from lattice simulations. Physical Review E, Vol.69 (No.5, Pt.1). pp. 1-8. doi:10.1103/PhysRevE.69.051917 ISSN 1063-651X.
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Official URL: http://dx.doi.org/10.1103/PhysRevE.69.051917
Abstract
Monte Carlo simulations of a Miyazawa-Jernigan lattice-polymer model indicate that, depending on the native structure's geometry, the model exhibits two broad classes of folding mechanisms for two-state folders. Folding to native structures of low contact order is driven by backbone distance and is characterized by a progressive accumulation of structure towards the native fold. By contrast, folding to high contact order targets is dominated by intermediate stage contacts not present in the native fold, yielding a more cooperative folding process.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QC Physics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Library of Congress Subject Headings (LCSH): | Protein folding | ||||
Journal or Publication Title: | Physical Review E | ||||
Publisher: | American Physical Society | ||||
ISSN: | 1063-651X | ||||
Official Date: | May 2004 | ||||
Dates: |
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Volume: | Vol.69 | ||||
Number: | No.5, Pt.1 | ||||
Number of Pages: | 8 | ||||
Page Range: | pp. 1-8 | ||||
DOI: | 10.1103/PhysRevE.69.051917 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 1 August 2016 | ||||
Date of first compliant Open Access: | 1 August 2016 | ||||
Funder: | Fundação para a Ciência e a Tecnologia (FCT) | ||||
Grant number: | BPD10083/2002 (FCT) |
Data sourced from Thomson Reuters' Web of Knowledge
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