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Folding and form : insights from lattice simulations

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Faisca, P. F. N., Telo da Gama, M. M. and Ball, R. C.. (2004) Folding and form : insights from lattice simulations. Physical Review E, Vol.69 (No.5, Pt.1). pp. 1-8. ISSN 1063-651X

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Official URL: http://dx.doi.org/10.1103/PhysRevE.69.051917

Abstract

Monte Carlo simulations of a Miyazawa-Jernigan lattice-polymer model indicate that, depending on the native structure's geometry, the model exhibits two broad classes of folding mechanisms for two-state folders. Folding to native structures of low contact order is driven by backbone distance and is characterized by a progressive accumulation of structure towards the native fold. By contrast, folding to high contact order targets is dominated by intermediate stage contacts not present in the native fold, yielding a more cooperative folding process.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics
Divisions:	Faculty of Science > Physics
Library of Congress Subject Headings (LCSH):	Protein folding
Journal or Publication Title:	Physical Review E
Publisher:	American Physical Society
ISSN:	1063-651X
Date:	May 2004
Volume:	Vol.69
Number:	No.5, Pt.1
Number of Pages:	8
Page Range:	pp. 1-8
Identification Number:	10.1103/PhysRevE.69.051917
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Fundação para a Ciência e a Tecnologia (FCT)
Grant number:	BPD10083/2002 (FCT)
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URI:	http://wrap.warwick.ac.uk/id/eprint/8367