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Study of (cyclic peptide)-polymer conjugate assemblies by small-angle neutron scattering
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Koh, Ming Liang, FitzGerald, Paul A., Warr, Gregory G., Jolliffe, Katrina A. and Perrier, Sébastien (2017) Study of (cyclic peptide)-polymer conjugate assemblies by small-angle neutron scattering. Chemistry - A European Journal, 22 (51). pp. 18419-18428. doi:10.1002/chem.201603091
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Official URL: http://dx.doi.org/10.1002/chem.201603091
Abstract
We present a fundamental study into the self-assembly of (cyclic peptide)–polymer conjugates as a versatile supramolecular motif to engineer nanotubes with defined structure and dimensions, as characterised in solution using small-angle neutron scattering (SANS). This work demonstrates the ability of the grafted polymer to stabilise and/or promote the formation of unaggregated nanotubes by the direct comparison to the unconjugated cyclic peptide precursor. This ideal case permitted a further study into the growth mechanism of self-assembling cyclic peptides, allowing an estimation of the cooperativity. Furthermore, we show the dependency of the nanostructure on the polymer and peptide chemical functionality in solvent mixtures that vary in the ability to compete with the intermolecular associations between cyclic peptides and ability to solvate the polymer shell.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Cyclic peptides, Self-assembly (Chemistry), Nanotubes | ||||||||
| Journal or Publication Title: | Chemistry - A European Journal | ||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||
| ISSN: | 0947-6539 | ||||||||
| Official Date: | 19 December 2017 | ||||||||
| Dates: |
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| Volume: | 22 | ||||||||
| Number: | 51 | ||||||||
| Page Range: | pp. 18419-18428 | ||||||||
| DOI: | 10.1002/chem.201603091 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Australian Research Council (ARC), Australia. Government, Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Monash-Warwick Alliance, National Science Foundation (U.S.) (NSF) | ||||||||
| Grant number: | DP140100241 (ARC), WM130055 (RSWRMA), DMR-0944772 (NSF) | ||||||||
| Adapted As: |
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