Koh, Ming Liang, FitzGerald, Paul A., Warr, Gregory G., Jolliffe, Katrina A. and Perrier, Sébastien (2017) Study of (cyclic peptide)-polymer conjugate assemblies by small-angle neutron scattering. Chemistry - A European Journal, 22 (51). pp. 18419-18428. doi:10.1002/chem.201603091 ISSN 0947-6539.

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Abstract

We present a fundamental study into the self-assembly of (cyclic peptide)–polymer conjugates as a versatile supramolecular motif to engineer nanotubes with defined structure and dimensions, as characterised in solution using small-angle neutron scattering (SANS). This work demonstrates the ability of the grafted polymer to stabilise and/or promote the formation of unaggregated nanotubes by the direct comparison to the unconjugated cyclic peptide precursor. This ideal case permitted a further study into the growth mechanism of self-assembling cyclic peptides, allowing an estimation of the cooperativity. Furthermore, we show the dependency of the nanostructure on the polymer and peptide chemical functionality in solvent mixtures that vary in the ability to compete with the intermolecular associations between cyclic peptides and ability to solvate the polymer shell.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Cyclic peptides, Self-assembly (Chemistry), Nanotubes
Journal or Publication Title:	Chemistry - A European Journal
Publisher:	Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:	0947-6539
Official Date:	19 December 2017
Dates:	Date Event 19 December 2017 Published 10 November 2016 Available 10 November 2016 Accepted
Volume:	22
Number:	51
Page Range:	pp. 18419-18428
DOI:	10.1002/chem.201603091
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Date of first compliant deposit:	15 November 2016
Date of first compliant Open Access:	10 November 2017
Funder:	Australian Research Council (ARC), Australia. Government, Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Monash-Warwick Alliance, National Science Foundation (U.S.) (NSF)
Grant number:	DP140100241 (ARC), WM130055 (RSWRMA), DMR-0944772 (NSF)
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