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Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism

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Britto, Mishan, Goulet, Adeline, Rizvi, Syeda, von Loeffelholz, Ottilie, Moores, Carolyn A. and Cross, R. A. (2016) Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proceedings of the National Academy of Sciences of the United States of America, 113 (47). E7483-E7489. doi:10.1073/pnas.1611581113 ISSN 0027-8424.

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Official URL: http://dx.doi.org/10.1073/pnas.1611581113

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Abstract

Molecular motors organize cells by hauling molecular cargoes along polymer tracks (actin filaments or microtubules). Until recently, the stepping direction of each motor was thought to be fixed; however, it now emerges that yeast kinesin-5 motors can reverse their stepping direction. How does this work? We show that the stepping direction of Cut7, a yeast kinesin-5 motor, depends on the level of motor crowding on the microtubule, and that crowding of Cut7 by non-Cut7 proteins also can drive reversal. To explain this, we propose that stepping of Cut7 in one direction is blocked by collisions with neighbors, whereas stepping in the other direction, being less space-hungry, is not. Crowding-dependent directional reversal is a hitherto-unsuspected aspect of motor-driven self-organization in cells.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Publisher: National Academy of Sciences
ISSN: 0027-8424
Official Date: 22 November 2016
Dates:
DateEvent
22 November 2016Published
9 November 2016Available
17 October 2016Accepted
Volume: 113
Number: 47
Page Range: E7483-E7489
DOI: 10.1073/pnas.1611581113
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 18 October 2018
Date of first compliant Open Access: 18 October 2018

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