The Library
In-hospital and 1-year mortality associated with diabetes in patients with acute heart failure : results from the ESC-HFA Heart Failure Long-Term Registry
Tools
Targher, Giovanni, Dauriz, Marco, Laroche, Cécile, Temporelli, Pier Luigi, Hassanein, Mahmoud, Seferovic, Petar M., Drozdz, Jaroslaw, Ferrari, Roberto, Anker, Stephan, Coats, Andrew J. S., Filippatos, Gerasimos, Crespo-Leiro, Maria G., Mebazaa, Alexandre, Piepoli, Massimo F., Maggioni, Aldo Pietro and Tavazzi, Luigi (2016) In-hospital and 1-year mortality associated with diabetes in patients with acute heart failure : results from the ESC-HFA Heart Failure Long-Term Registry. European Journal of Heart Failure . doi:10.1002/ejhf.679 ISSN 1388-9842.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1002/ejhf.679
Abstract
Aims
The aim of this study was to evaluate the in-hospital and 1-year prognostic impact of diabetes and elevated blood glucose levels at hospital admission in patients with acute heart failure (HF).
Methods and results
We studied a multinational cohort of 6926 hospitalized patients with acute HF enrolled in the European Society of Cardiology (ESC) and Heart Failure Association (HFA) Long-Term Registry, of whom 49.4% (n = 3422) had known or previously undiagnosed diabetes (defined as self-reported history, or medication use, or fasting glucose levels ≥7.0 mmol/L or haemoglobin A1c ≥6.5%). Compared with those without diabetes, patients with known or previously undiagnosed diabetes had higher cumulative rates of in-hospital mortality, 1-year mortality, and 1-year HF re-hospitalization that occurred independently of multiple clinical risk factors: in-hospital mortality [6.8 vs. 4.4%; adjusted hazard ratio (HR) 1.774; 95% confidence interval (CI) 1.282–2.456, P < 0.001], 1-year all-cause mortality (27.5 vs. 24%; adjusted HR 1.162; 95% CI 1.020–1.325, P = 0.024), and 1-year hospital re-admissions for HF (23.2 vs. 18.5%; adjusted HR 1.320; 95% CI 1.139–1.530, P < 0.001). Moreover, elevated admission blood glucose concentrations were powerfully prognostic for in-hospital mortality, but not for 1-year mortality or re-hospitalizations, in both patients with and without diabetes.
Conclusions
Among patients hospitalized for acute HF, the presence of diabetes is independently associated with an increased risk of in-hospital mortality, 1-year all-cause mortality, and 1-year re-hospitalizations for HF, underscoring the need for more effective and personalized treatments of diabetes in this particularly high-risk patient population.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
Journal or Publication Title: | European Journal of Heart Failure | ||||||||
Publisher: | John Wiley & Sons Ltd. | ||||||||
ISSN: | 1388-9842 | ||||||||
Official Date: | 28 October 2016 | ||||||||
Dates: |
|
||||||||
DOI: | 10.1002/ejhf.679 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |