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Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum?
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Wilkes, Sally R., Williams, Hywel C., Ormerod, Anthony D., Craig, Fiona E., Greenlaw, Nicola, Norrie, John, Mitchell, Eleanor J., Mason, James and Thomas, Kim S. (2016) Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? Journal of the American Academy of Dermatology, 75 (6). 1216-1220.e2. doi:10.1016/j.jaad.2016.07.049 ISSN 0190-9622.
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Official URL: http://dx.doi.org/10.1016/j.jaad.2016.07.049
Abstract
Background
Pyoderma gangrenosum is a rare inflammatory skin condition. Two prospective studies have evaluated treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks.
Objective
Using data from both studies we assessed the predictive value of 3 early predictors for healing at 6 months: speed of healing, Investigator Global Assessment (IGA), and resolution of inflammation, recorded at 2 and 6 weeks.
Methods
Logistic regression models were applied and the effectiveness of the 3 measures was assessed through estimating the positive and negative predictive values and the area under the receiver operating characteristic curve.
Results
The positive and negative predictive value at 6 weeks were, respectively, 63.5% (95% confidence interval [CI] 52.4%-73.7%) and 74.6% (95% CI 62.5%-84.5%) for speed of healing; 80% (95% CI 68.7%-88.6%) and 74.2% (95% CI 64.1%-82.7%) for IGA; and 72.1% (95% CI 59.9%-82.3%) and 68.1% (95% CI 57.7%-77.3%) for resolution of inflammation. IGA had the best combined positive predictive value, negative predictive value, and area under the receiver operating characteristic curve at 2 and 6 weeks.
Limitations
We were limited by data available from existing datasets.
Conclusion
Speed of healing, IGA, and resolution of inflammation were all shown to be good predictors of eventual healing of pyoderma gangrenosum.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RL Dermatology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| Library of Congress Subject Headings (LCSH): | Pyoderma -- Treatment, Skin -- Ulcers -- Treatment | ||||||||
| Journal or Publication Title: | Journal of the American Academy of Dermatology | ||||||||
| Publisher: | Mosby, Inc. | ||||||||
| ISSN: | 0190-9622 | ||||||||
| Official Date: | December 2016 | ||||||||
| Dates: |
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| Volume: | 75 | ||||||||
| Number: | 6 | ||||||||
| Page Range: | 1216-1220.e2 | ||||||||
| DOI: | 10.1016/j.jaad.2016.07.049 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 12 December 2016 | ||||||||
| Date of first compliant Open Access: | 10 October 2017 | ||||||||
| Funder: | National Institute for Health Research (Great Britain) (NIHR), UK Clinical Research Network (UKCRN), UK Clinical Research Network Collaboration (UKCRC), NHS Research Scotland (NRS) |
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