The Library
Implementing nonlinear feedback controllers using DNA strand displacement reactions
Tools
Tools
Tools
Sawlekar, Rucha, Montefusco, Francesco, Kulkarni, Vishwesh V. and Bates, Declan (2016) Implementing nonlinear feedback controllers using DNA strand displacement reactions. IEEE Transactions on NanoBioscience, 15 (5). pp. 443-454. doi:DOI: 10.1109/TNB.2016.2560764
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP_ieee_trans_nbs_accepted.pdf - Accepted Version - Requires a PDF viewer. Download (1423Kb) |
Official URL: http://ieeexplore.ieee.org/document/7463078/
Abstract
We show how an important class of nonlinear feedback controllers can be designed using idealized abstract chemical reactions that can be implemented via DNA strand dis-placement (DSD) reactions. Exploiting chemical reaction networks (CRNs) as a programming language for the design of complex circuits and networks, we show how a set of unimolecular and bimolecular reactions can be used to realize ultrasensitive input-output dynamics that produce a nonlinear quasi sliding mode (QSM) feedback controller. The kinetics of the required chemical reactions can then be implemented as enzyme-free, entropy-driven DNA reactions using DNA strand displacement via Watson-Crick base pairing and branch migration. We demonstrate that the closed loop response of the nonlinear QSM controller outperforms a traditional linear controller by facilitating much faster tracking response dynamics without introducing overshoots in the transient response. The resulting controller is highly modular and is less affected by retroactivity effects than standard linear designs.
| Item Type: | Journal Article | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history T Technology > TA Engineering (General). Civil engineering (General) |
||||||||||||
| Divisions: | Faculty of Science > Engineering | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Synthetic biology -- Industrial applications, DNA, Substitution reactions -- Mathematical models, Biomedical engineering | ||||||||||||
| Journal or Publication Title: | IEEE Transactions on NanoBioscience | ||||||||||||
| Publisher: | IEEE | ||||||||||||
| ISSN: | 1536-1241 | ||||||||||||
| Official Date: | 29 April 2016 | ||||||||||||
| Dates: |
|
||||||||||||
| Date of first compliant deposit: | 30 November 2016 | ||||||||||||
| Volume: | 15 | ||||||||||||
| Number: | 5 | ||||||||||||
| Page Range: | pp. 443-454 | ||||||||||||
| DOI: | DOI: 10.1109/TNB.2016.2560764 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| RIOXX Funder/Project Grant: |
|
||||||||||||
| Open Access Version: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
