Kulkarni, Vishwesh V., El Menjra, Lina, Carbonell, Pablo and Faulon, Jean-Loup (2016) Integrated predictive genome-scale models to improve the metabolic re-engineering efficiency. In: 8th International Workshop on Bio-Design Automation, Newcastle-upon-Tyne, UK, 16-18 Aug 2016

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Abstract

One of the most common applications of metabolic circuits is to produce a desired chemical in a chassis organism, such as the Escherichia coli (E. coli), by importing heterologous genes encoding for the enzymes that participate in the biosynthetic pathway. Recently, an automated pipeline named RetroPath was developed to synthesise embedded metabolic circuits [1]. These circuits are to be embedded in E. coli for a wide range of applications such as regulating biomass productions, sensing specifc molecules, processing specific molecules, and releasing specific molecules. In this paper, we improve the efficiency of RetroPath via quadratic programming.

Item Type:	Conference Item (Speech)
Subjects:	Q Science > QP Physiology Q Science > QR Microbiology
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Escherichia coli, Biosynthesis
Official Date:	18 August 2016
Dates:	Date Event 18 August 2016 Published 16 June 2016 Accepted 20 March 2016 Submitted
Status:	Peer Reviewed
Publication Status:	Published
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	BB/M017702/1
Conference Paper Type:	Speech
Title of Event:	8th International Workshop on Bio-Design Automation
Type of Event:	Workshop
Location of Event:	Newcastle-upon-Tyne, UK
Date(s) of Event:	16-18 Aug 2016
Related URLs:	Organisation

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