The Library
Biomolecular implementation of a quasi sliding mode feedback controller based on DNA strand displacement reactions
Tools
Sawlekar, Rucha, Montefusco, Francesco, Kulkarni, Vishwesh V. and Bates, Declan (2015) Biomolecular implementation of a quasi sliding mode feedback controller based on DNA strand displacement reactions. In: 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, Italy, August 25-29, 2015. Published in: Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society pp. 949-952. ISSN DOI: 10.1109/EMBC.2015.7318520.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://doi.org/10.1109/EMBC.2015.7318520
Abstract
A fundamental aim of synthetic biology is to achieve the capability to design and implement robust embedded biomolecular feedback control circuits. An approach to realize this objective is to use abstract chemical reaction networks (CRNs) as a programming language for the design of complex circuits and networks. Here, we employ this approach to facilitate the implementation of a class of nonlinear feedback controllers based on sliding mode control theory. We show how a set of two-step irreversible reactions with ultrasensitive response dynamics can provide a biomolecular implementation of a nonlinear quasi sliding mode (QSM) controller. We implement our controller in closed-loop with a prototype of a biological pathway and demonstrate that the nonlinear QSM controller outperforms a traditional linear controller by facilitating faster tracking response dynamics without introducing overshoots in the transient response.
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |