Li, Zhen, Sun, Liang, Zhang, Yufei, Dove, Andrew P., O’Reilly, Rachel K. and Chen, Guosong (2016) Shape effect of glyco-nanoparticles on macrophage cellular uptake and immune response. ACS Macro Letters, 5 (9). pp. 1059-1064. doi:10.1021/acsmacrolett.6b00419 ISSN 2161-1653.

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Abstract

The shells of various poly(dl-lactide)-b-poly(acrylic acid) (PDLLA-b-PAA) spherical micelles and poly(l-lactide)-b-poly(acrylic acid) (PLLA-b-PAA) cylindrical micelles were functionalized with mannose to yield glyco-nanoparticles (GNPs) with different shapes and dimensions. All of these GNPs were shown to have good biocompatibility (up to 1 mg/mL). Cellular uptake experiments using RAW 264.7 have shown that the spherical GNPs were internalized to a much greater extent than the cylindrical GNPs and such a phenomenon was attributed to their different endocytosis pathways. It was demonstrated that spherical GNPs were internalized based on clathrin- and caveolin-mediated endocytosis while cylindrical GNPs mainly depended on clathrin-mediated endocytosis. We also found that longer cylindrical GNPs (Ln × Wn = 215 × 47 nm) can induce an inflammatory response (specifically interleukin 6) more efficiently than shorter cylindrical GNPs (Ln × Wn = 99 × 50 nm) and spherical GNPs (Dn = 46 nm).

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Micelles, Endocytosis
Journal or Publication Title:	ACS Macro Letters
Publisher:	American Chemical Society
ISSN:	2161-1653
Official Date:	20 September 2016
Dates:	Date Event 20 September 2016 Published 11 September 2016 Available 29 August 2016 Accepted 1 June 2016 Submitted
Volume:	5
Number:	9
Page Range:	pp. 1059-1064
DOI:	10.1021/acsmacrolett.6b00419
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	29 November 2016
Date of first compliant Open Access:	1 December 2016
Funder:	Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Engineering and Physical Sciences Research Council (EPSRC), Royal Society (Great Britain), European Research Council (ERC)
Grant number:	91527305, 21474020, 91227203, 5141101211, 51322306 (NSFC)

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