
The Library
Shape effect of glyco-nanoparticles on macrophage cellular uptake and immune response
Tools
Li, Zhen, Sun, Liang, Zhang, Yufei, Dove, Andrew P., O’Reilly, Rachel K. and Chen, Guosong (2016) Shape effect of glyco-nanoparticles on macrophage cellular uptake and immune response. ACS Macro Letters, 5 (9). pp. 1059-1064. doi:10.1021/acsmacrolett.6b00419 ISSN 2161-1653.
![]() |
PDF
WRAP_mz6b00419.pdf - Published Version - Requires a PDF viewer. Download (5Mb) |
Official URL: http://dx.doi.org/10.1021/acsmacrolett.6b00419
Abstract
The shells of various poly(dl-lactide)-b-poly(acrylic acid) (PDLLA-b-PAA) spherical micelles and poly(l-lactide)-b-poly(acrylic acid) (PLLA-b-PAA) cylindrical micelles were functionalized with mannose to yield glyco-nanoparticles (GNPs) with different shapes and dimensions. All of these GNPs were shown to have good biocompatibility (up to 1 mg/mL). Cellular uptake experiments using RAW 264.7 have shown that the spherical GNPs were internalized to a much greater extent than the cylindrical GNPs and such a phenomenon was attributed to their different endocytosis pathways. It was demonstrated that spherical GNPs were internalized based on clathrin- and caveolin-mediated endocytosis while cylindrical GNPs mainly depended on clathrin-mediated endocytosis. We also found that longer cylindrical GNPs (Ln × Wn = 215 × 47 nm) can induce an inflammatory response (specifically interleukin 6) more efficiently than shorter cylindrical GNPs (Ln × Wn = 99 × 50 nm) and spherical GNPs (Dn = 46 nm).
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QH Natural history |
||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Micelles, Endocytosis | ||||||||||
Journal or Publication Title: | ACS Macro Letters | ||||||||||
Publisher: | American Chemical Society | ||||||||||
ISSN: | 2161-1653 | ||||||||||
Official Date: | 20 September 2016 | ||||||||||
Dates: |
|
||||||||||
Volume: | 5 | ||||||||||
Number: | 9 | ||||||||||
Page Range: | pp. 1059-1064 | ||||||||||
DOI: | 10.1021/acsmacrolett.6b00419 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 29 November 2016 | ||||||||||
Date of first compliant Open Access: | 1 December 2016 | ||||||||||
Funder: | Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Engineering and Physical Sciences Research Council (EPSRC), Royal Society (Great Britain), European Research Council (ERC) | ||||||||||
Grant number: | 91527305, 21474020, 91227203, 5141101211, 51322306 (NSFC) |
Request changes or add full text files to a record
Repository staff actions (login required)
![]() |
View Item |
Downloads
Downloads per month over past year