The Library
Shape effect of glyco-nanoparticles on macrophage cellular uptake and immune response
Tools
Tools
Tools
Li, Zhen, Sun, Liang, Zhang, Yufei, Dove, Andrew P., O’Reilly, Rachel K. and Chen, Guosong (2016) Shape effect of glyco-nanoparticles on macrophage cellular uptake and immune response. ACS Macro Letters, 5 (9). pp. 1059-1064. doi:10.1021/acsmacrolett.6b00419
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP_mz6b00419.pdf - Published Version - Requires a PDF viewer. Download (5Mb) |
Official URL: http://dx.doi.org/10.1021/acsmacrolett.6b00419
Abstract
The shells of various poly(dl-lactide)-b-poly(acrylic acid) (PDLLA-b-PAA) spherical micelles and poly(l-lactide)-b-poly(acrylic acid) (PLLA-b-PAA) cylindrical micelles were functionalized with mannose to yield glyco-nanoparticles (GNPs) with different shapes and dimensions. All of these GNPs were shown to have good biocompatibility (up to 1 mg/mL). Cellular uptake experiments using RAW 264.7 have shown that the spherical GNPs were internalized to a much greater extent than the cylindrical GNPs and such a phenomenon was attributed to their different endocytosis pathways. It was demonstrated that spherical GNPs were internalized based on clathrin- and caveolin-mediated endocytosis while cylindrical GNPs mainly depended on clathrin-mediated endocytosis. We also found that longer cylindrical GNPs (Ln × Wn = 215 × 47 nm) can induce an inflammatory response (specifically interleukin 6) more efficiently than shorter cylindrical GNPs (Ln × Wn = 99 × 50 nm) and spherical GNPs (Dn = 46 nm).
| Item Type: | Journal Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history |
||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
| Library of Congress Subject Headings (LCSH): | Micelles, Endocytosis | ||||||||||
| Journal or Publication Title: | ACS Macro Letters | ||||||||||
| Publisher: | American Chemical Society | ||||||||||
| ISSN: | 2161-1653 | ||||||||||
| Official Date: | 20 September 2016 | ||||||||||
| Dates: |
|
||||||||||
| Volume: | 5 | ||||||||||
| Number: | 9 | ||||||||||
| Page Range: | pp. 1059-1064 | ||||||||||
| DOI: | 10.1021/acsmacrolett.6b00419 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Engineering and Physical Sciences Research Council (EPSRC), Royal Society (Great Britain), European Research Council (ERC) | ||||||||||
| Grant number: | 91527305, 21474020, 91227203, 5141101211, 51322306 (NSFC) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
