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Fluorescent labelling and biodistribution of latex nanoparticles formed by surfactant-free RAFT emulsion polymerisation
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Poon, C. K., Tang, O., Chen, X.-C., Kim, B., Hartlieb, Matthias, Pollock, C. A., Hawkett, B. S. and Perrier, Sébastien (2017) Fluorescent labelling and biodistribution of latex nanoparticles formed by surfactant-free RAFT emulsion polymerisation. Macromolecular Bioscience, 17 (10). 1600366. doi:10.1002/mabi.201600366 ISSN 1616-5187.
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Official URL: http://doi.org/10.1002/mabi.201600366
Abstract
We report the preparation of a novel range of functional polyacrylamide stabilised polystyrene nanoparticles, obtained by surfactant-free reversible addition-fragmentation chain transfer (RAFT) emulsion polymerisation, their fluorescent tagging, cellular uptake and
biodistribution. We show the versatility of the RAFT emulsion process for the design of functional nanoparticles of well-defined size that can be used as drug delivery vectors.
Functionalisation with a fluorescent tag offers a useful visualisation tool for tracing, localisation and clearance studies of these carriers in biological models. The studies were carried out by labelling the sterically stabilised latex particles chemically with rhodamine B. The fluorescent particles were incubated in a healthy human renal proximal tubular cell line model, and intravenously injected into a mouse model. Cellular localisation and biodistribution of these particles on the biological models were explored.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Fragmentation reactions | ||||||||
| Journal or Publication Title: | Macromolecular Bioscience | ||||||||
| Publisher: | Wiley | ||||||||
| ISSN: | 1616-5187 | ||||||||
| Official Date: | October 2017 | ||||||||
| Dates: |
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| Volume: | 17 | ||||||||
| Number: | 10 | ||||||||
| Article Number: | 1600366 | ||||||||
| DOI: | 10.1002/mabi.201600366 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 7 December 2016 | ||||||||
| Date of first compliant Open Access: | 8 October 2018 |
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