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The enigmatic Esx proteins : looking beyond mycobacteria
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Unnikrishnan, Meera, Constantinidou, Chrystala, Palmer, Tracy and Pallen, Mark J. (2017) The enigmatic Esx proteins : looking beyond mycobacteria. Trends in Microbiology, 25 (3). pp. 192-204. doi:10.1016/j.tim.2016.11.004
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Official URL: http://dx.doi.org/10.1016/j.tim.2016.11.004
Abstract
Bacteria export proteins across membranes using a range of transport machineries. Type VII secretion systems (T7SSs), originally described in mycobacteria, are now known to be widespread across diverse bacterial phyla. Recent studies have characterized secretion components and mechanisms of type VII secretion in pathogenic and environmental bacteria. A variety of functions have been attributed to T7SS substrates, including interactions with eukaryotes and with other bacteria. Here, we evaluate the growing body of knowledge on T7SSs, with focus on the nonmycobacterial systems, reviewing their phylogenetic distribution, structure and function in diverse settings.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Mycobacteria, Pathogenic bacteria , Proteins | ||||||||
| Journal or Publication Title: | Trends in Microbiology | ||||||||
| Publisher: | Elsevier Ltd | ||||||||
| ISSN: | 0966-842X | ||||||||
| Official Date: | March 2017 | ||||||||
| Dates: |
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| Volume: | 25 | ||||||||
| Number: | 3 | ||||||||
| Page Range: | pp. 192-204 | ||||||||
| DOI: | 10.1016/j.tim.2016.11.004 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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