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Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
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Won, Sangho, Richards, Sarah-Jane, Walker, Marc and Gibson, Matthew I. (2017) Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition. Nanoscale Horizons, 2017 (2). pp. 106-109. doi:10.1039/C6NH00202A ISSN 2055-6756.
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Official URL: http://dx.doi.org/10.1039/C6NH00202A
Abstract
Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in Nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Nanoscale Horizons | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 2055-6756 | ||||||||||
Official Date: | March 2017 | ||||||||||
Dates: |
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Volume: | 2017 | ||||||||||
Number: | 2 | ||||||||||
Page Range: | pp. 106-109 | ||||||||||
DOI: | 10.1039/C6NH00202A | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 15 December 2016 | ||||||||||
Date of first compliant Open Access: | 20 December 2016 |
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