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Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

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Won, Sangho, Richards, Sarah-Jane, Walker, Marc and Gibson, Matthew I. (2017) Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition. Nanoscale Horizons, 2017 (2). pp. 106-109. doi:10.1039/C6NH00202A

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Official URL: http://dx.doi.org/10.1039/C6NH00202A

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Abstract

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in Nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

Item Type: Journal Article
Divisions: Faculty of Science > Chemistry
Faculty of Science > Physics
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Nanoscale Horizons
Publisher: Royal Society of Chemistry
ISSN: 2055-6756
Official Date: March 2017
Dates:
DateEvent
March 2017Published
14 December 2016Available
14 December 2016Accepted
11 November 2016Submitted
Volume: 2017
Number: 2
Page Range: pp. 106-109
DOI: 10.1039/C6NH00202A
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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