Won, Sangho, Richards, Sarah-Jane, Walker, Marc and Gibson, Matthew I. (2017) Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition. Nanoscale Horizons, 2017 (2). pp. 106-109. doi:10.1039/C6NH00202A ISSN 2055-6756.

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Abstract

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in Nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Nanoscale Horizons
Publisher:	Royal Society of Chemistry
ISSN:	2055-6756
Official Date:	March 2017
Dates:	Date Event March 2017 Published 14 December 2016 Available 14 December 2016 Accepted 11 November 2016 Submitted
Volume:	2017
Number:	2
Page Range:	pp. 106-109
DOI:	10.1039/C6NH00202A
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	15 December 2016
Date of first compliant Open Access:	20 December 2016

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