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Regioregular alternating polyampholytes have enhanced biomimetic ice recrystallization activity compared to random copolymers and the role of side chain verses main chain hydrophobicity
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Stubbs, Christopher D., Lipecki, Julia and Gibson, Matthew I. (2017) Regioregular alternating polyampholytes have enhanced biomimetic ice recrystallization activity compared to random copolymers and the role of side chain verses main chain hydrophobicity. Biomacromolecules, 18 (1). pp. 295-302. doi:10.1021/acs.biomac.6b01691
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Official URL: http://dx.doi.org/10.1021/acs.biomac.6b01691
Abstract
Antifreeze proteins from polar fish species are potent ice recrystallization inhibitors (IRIs) effectively stopping all ice growth. Additives which have IRI activity have been shown to enhance cellular cryopreservation with potential to improve the distribution of donor cells and tissue. Polyampholytes, polymers with both anionic and cationic side chains, are a rapidly emerging class of polymer cryoprotectants, but their mode of action and the structural features essential for activity are not clear. Here regio-regular polyampholytes are synthesized from maleic anhydride co-polymers to enable stoichiometric installation of the charged groups, ensuring regio-regularity which is not possible using conventional random co-polymerisation. A modular synthetic strategy is employed to enable the backbone and side chain hydrophobicity to be varied, with side chain hydrophobicity found to have a profound effect on the IRI activity. The activity of the regio-regular polymers was found to be superior to those derived from a standard random copolymerisation with statistical incorporation of monomers, demonstrating that sequence composition is crucial to the activity of IRI active polyampholytes.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QD Chemistry | ||||||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Polyampholytes, Copolymers, Biomimetics, Ice crystals | ||||||||||||
| Journal or Publication Title: | Biomacromolecules | ||||||||||||
| Publisher: | American Chemical Society | ||||||||||||
| ISSN: | 1525-7797 | ||||||||||||
| Official Date: | 9 January 2017 | ||||||||||||
| Dates: |
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| Volume: | 18 | ||||||||||||
| Number: | 1 | ||||||||||||
| Page Range: | pp. 295-302 | ||||||||||||
| DOI: | 10.1021/acs.biomac.6b01691 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| Funder: | European Research Council (ERC), Royal Society (Great Britain), Midlands Integrative Biosciences Training Partnership (MIBTP) | ||||||||||||
| Grant number: | CRYOMAT 638661 (ERC), BB/M01116X/1 (MIBTP) | ||||||||||||
| RIOXX Funder/Project Grant: |
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