%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Matt J. Keeling, Thomas House, Alison J. Cooper, Lorenzo Pellis
Systematic Approximations to Susceptible-Infectious-Susceptible Dynamics on Networks
www.ploscompbiol.org
www.ploscompbiol.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 10 0 R/Contents 11 0 R/TrimBox[0 0 612 792]>>
endobj
10 0 obj
[12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R]
endobj
12 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref001)>>
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref009)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref002)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref010)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref013)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref014)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref015)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref001)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref016)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref017)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref005)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref016)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref018)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref019)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref020)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref021)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref022)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref023)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref024)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref025)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref028)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref029)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref032)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref033)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref034)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref035)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref037)>>
endobj
11 0 obj
[39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R]
endobj
39 0 obj
<>stream
q
0.83 0.64 0.02 0 k
203.4142 674.9858 m
208.1764 674.9858 l
h
f*
213.3354 674.9858 m
218.0976 674.9858 l
h
f*
241.3417 596.9764 m
246.0472 596.9764 l
h
f*
250.526 596.9764 m
260.0504 596.9764 l
h
f*
265.2094 596.9764 m
274.7339 596.9764 l
h
f*
252.737 571.011 m
262.2047 571.011 l
h
f*
308.6362 571.011 m
318.1606 571.011 l
h
f*
323.4331 532.0063 m
328.1953 532.0063 l
h
f*
340.1575 519.0236 m
349.6252 519.0236 l
h
f*
538.8661 414.9921 m
548.3339 414.9921 l
h
f*
327.1181 375.9874 m
331.8803 375.9874 l
h
f*
336.2457 375.9874 m
345.7701 375.9874 l
h
f*
350.1354 375.9874 m
359.6598 375.9874 l
h
f*
223.9937 259.0299 m
233.5181 259.0299 l
h
f*
458.1354 259.0299 m
467.6598 259.0299 l
h
f*
348.2646 245.9906 m
357.789 245.9906 l
h
f*
501.1087 245.9906 m
510.6331 245.9906 l
h
f*
309.2031 206.9858 m
318.6709 206.9858 l
h
f*
323.1496 206.9858 m
332.674 206.9858 l
h
f*
310.8472 181.0205 m
320.3717 181.0205 l
h
f*
325.5307 181.0205 m
335.0551 181.0205 l
h
f*
516.3591 154.9984 m
525.8268 154.9984 l
h
f*
531.0425 154.9984 m
540.5102 154.9984 l
h
f*
456.378 142.0157 m
465.9024 142.0157 l
h
f*
529.1717 142.0157 m
538.6961 142.0157 l
h
f*
500.6551 128.9764 m
510.1228 128.9764 l
h
f*
515.3386 128.9764 m
524.8063 128.9764 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(There)Tj
2.5738 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(strong)Tj
2.7723 0 Td
(and)Tj
1.7291 0 Td
(deep)Tj
2.1147 0 Td
(connection)Tj
4.7168 0 Td
(between)Tj
3.5263 0 Td
(networks)Tj
3.9118 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(spread)Tj
2.8573 0 Td
(of)Tj
1.0148 0 Td
(infectious)Tj
4.1329 0 Td
(diseases)Tj
-34.0495 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
2.5908 0 Td
(Virtually)Tj
3.7644 0 Td
(all)Tj
1.1452 0 Td
(infections)Tj
4.1499 0 Td
(can)Tj
1.627 0 Td
(be)Tj
1.1509 0 Td
(thought)Tj
3.3732 0 Td
(of)Tj
1.0148 0 Td
(as)Tj
1.0148 0 Td
(propagating)Tj
5.0456 0 Td
(through)Tj
3.4413 0 Td
(a)Tj
0.6576 0 Td
(network)Tj
3.549 0 Td
(of)Tj
1.0148 0 Td
(\(epidemi-)Tj
-33.5393 -1.2982 Td
(ologically-relevant\))Tj
7.9086 0 Td
(contacts)Tj
3.5092 0 Td
(between)Tj
3.532 0 Td
(individuals)Tj
4.6488 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(population,)Tj
4.8132 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(structure)Tj
3.821 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
-35.223 -1.2983 Td
(underlying)Tj
4.5977 0 Td
(network)Tj
3.5433 0 Td
(determining)Tj
5.1817 0 Td
(much)Tj
2.5115 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(infection)Tj
3.7871 0 Td
(dynamics.)Tj
4.2746 0 Td
(Therefore)Tj
4.1669 0 Td
(an)Tj
1.2019 0 Td
(understanding)Tj
-31.7478 -1.3039 Td
(of)Tj
1.0147 0 Td
(population-level)Tj
6.7351 0 Td
(transmission)Tj
5.3631 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(scale)Tj
2.109 0 Td
(of)Tj
1.0148 0 Td
(individual)Tj
4.2859 0 Td
(hosts)Tj
2.2791 0 Td
(is)Tj
0.8447 0 Td
(closely)Tj
2.8856 0 Td
(linked)Tj
2.727 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(study)Tj
2.3924 0 Td
(of)Tj
-35.7503 -1.2983 Td
(the)Tj
1.4683 0 Td
(properties)Tj
4.2803 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(underlying)Tj
4.5978 0 Td
(transmission)Tj
5.3688 0 Td
(network.)Tj
3.77 0 Td
(Recent)Tj
2.9594 0 Td
(advances)Tj
3.8267 0 Td
(in)Tj
1.0375 0 Td
(network)Tj
3.5489 0 Td
(science)Tj
-33.3408 -1.2982 Td
(have)Tj
2.0579 0 Td
(highlighted)Tj
4.7622 0 Td
(how)Tj
1.9388 0 Td
(both)Tj
2.0637 0 Td
(local)Tj
2.0749 0 Td
(and)Tj
1.7291 0 Td
(global)Tj
2.6249 0 Td
(structure)Tj
3.8267 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(network)Tj
3.5489 0 Td
(are)Tj
1.4514 0 Td
(key)Tj
1.593 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(dynamics)Tj
4.0535 0 Td
(of)Tj
-36.714 -1.304 Td
(infection)Tj
3.7927 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(10)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
-3.8551 -1.2982 Td
(While)Tj
2.6532 0 Td
(networks)Tj
3.9118 0 Td
(are)Tj
1.4456 0 Td
(being)Tj
2.4321 0 Td
(increasingly)Tj
5.0287 0 Td
(used)Tj
2.0636 0 Td
(for)Tj
1.3833 0 Td
(airborne)Tj
3.651 0 Td
(and)Tj
1.7291 0 Td
(close-contact)Tj
5.4652 0 Td
(infections)Tj
4.1555 0 Td
(\(such)Tj
-35.1153 -1.2983 Td
(as)Tj
1.0147 0 Td
(influenza)Tj
3.9175 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
1.8482 0 Td
(and)Tj
1.7291 0 Td
(RSV)Tj
2.0126 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(]\))Tj
2.194 0 Td
(which)Tj
2.6475 0 Td
(spread)Tj
2.8573 0 Td
(through)Tj
3.4469 0 Td
(social)Tj
2.4548 0 Td
(contacts,)Tj
3.7417 0 Td
(the)Tj
1.4684 0 Td
(epidemiological)Tj
6.5593 0 Td
(net-)Tj
-35.892 -1.2983 Td
(work)Tj
2.279 0 Td
(literature)Tj
3.8778 0 Td
(was)Tj
1.7007 0 Td
(originally)Tj
4.0252 0 Td
(formulated)Tj
4.6658 0 Td
(for)Tj
1.389 0 Td
(sexually)Tj
3.3789 0 Td
(transmitted)Tj
4.8642 0 Td
(infections)Tj
4.1555 0 Td
(\(STIs\))Tj
2.6873 0 Td
(where)Tj
2.6475 0 Td
(the)Tj
-35.6709 -1.3039 Td
(network)Tj
3.5489 0 Td
(is)Tj
0.8447 0 Td
(generally)Tj
3.8381 0 Td
(more)Tj
2.3414 0 Td
(clearly)Tj
2.8176 0 Td
(defined.)Tj
3.4526 0 Td
(Classic)Tj
2.9764 0 Td
(examples)Tj
3.9061 0 Td
(include)Tj
3.1861 0 Td
(homosexual)Tj
5.04 0 Td
(contact)Tj
3.1521 0 Td
(net-)Tj
-35.104 -1.2982 Td
(works)Tj
2.6362 0 Td
(from)Tj
2.211 0 Td
(early)Tj
2.1486 0 Td
(HIV)Tj
2.0183 0 Td
(studies)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(])Tj
1.3776 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(Colorado-Springs)Tj
7.3416 0 Td
(study)Tj
2.3868 0 Td
(of)Tj
1.0148 0 Td
(sexual)Tj
2.6816 0 Td
(contacts)Tj
3.5149 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
-34.5484 -1.2983 Td
(high-risk)Tj
3.855 0 Td
(heterosexual)Tj
5.2271 0 Td
(population)Tj
4.5921 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
2.0749 0 Td
(While)Tj
2.6476 0 Td
(a)Tj
0.6576 0 Td
(focus)Tj
2.3244 0 Td
(on)Tj
1.2756 0 Td
(STIs)Tj
2.0069 0 Td
(has)Tj
1.542 0 Td
(substantial)Tj
4.5071 0 Td
(advantages)Tj
4.5978 0 Td
(in)Tj
-35.3081 -1.3039 Td
(terms)Tj
2.4944 0 Td
(of)Tj
1.0148 0 Td
(determining)Tj
5.1817 0 Td
(the)Tj
1.4684 0 Td
(network,)Tj
3.7757 0 Td
(it)Tj
0.7823 0 Td
(also)Tj
1.7688 0 Td
(places)Tj
2.6249 0 Td
(constraints)Tj
4.6375 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(epidemiological)Tj
6.565 0 Td
(dynamics)Tj
-33.0574 -1.2983 Td
(that)Tj
1.7744 0 Td
(need)Tj
2.1487 0 Td
(to)Tj
1.0204 0 Td
(be)Tj
1.1509 0 Td
(considered.)Tj
4.8302 0 Td
(The)Tj
1.7802 0 Td
(overwhelming)Tj
5.9583 0 Td
(majority)Tj
3.6284 0 Td
(of)Tj
1.0148 0 Td
(STIs)Tj
2.0069 0 Td
(\(e.g.)Tj
1.8992 0 Td
(chlamydia)Tj
4.354 0 Td
(or)Tj
1.0998 0 Td
(gonorrhoea,)Tj
-32.6662 -1.2982 Td
(although)Tj
3.753 0 Td
(not)Tj
1.5761 0 Td
(HIV\))Tj
2.3584 0 Td
(can)Tj
1.627 0 Td
(be)Tj
1.1509 0 Td
(approximated)Tj
5.7996 0 Td
(using)Tj
2.3925 0 Td
(the)Tj
1.4683 0 Td
(Susceptible-Infected-Susce)Tj
10.6582 0 Td
(ptible)Tj
2.4775 0 Td
(\(SIS\))Tj
2.194 0 Td
(para-)Tj
-35.4555 -1.304 Td
(digm,)Tj
2.5228 0 Td
(where)Tj
2.6532 0 Td
(infected)Tj
3.4185 0 Td
(individuals)Tj
4.6488 0 Td
(are)Tj
1.4514 0 Td
(treated)Tj
2.9933 0 Td
(and)Tj
1.7292 0 Td
(recover)Tj
3.1974 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(susceptible)Tj
4.5751 0 Td
(state,)Tj
2.262 0 Td
(and)Tj
1.7291 0 Td
(hence)Tj
2.5682 0 Td
(are)Tj
-36.2435 -1.2982 Td
(able)Tj
1.8311 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1451 0 Td
(re-infected)Tj
4.5695 0 Td
(multiple)Tj
3.5659 0 Td
(times.)Tj
2.6136 0 Td
(Although)Tj
4.0024 0 Td
(SIS)Tj
1.5137 0 Td
(models)Tj
3.1068 0 Td
(are)Tj
1.4457 0 Td
(inherently)Tj
4.3313 0 Td
(lower-dimensional)Tj
-29.1513 -1.2983 Td
(than)Tj
2.0295 0 Td
(their)Tj
2.1033 0 Td
(SIR)Tj
1.6611 0 Td
(\(Susceptible-Infected-Recovered\))Tj
13.5212 0 Td
(counterparts,)Tj
5.5275 0 Td
(potential)Tj
3.7587 0 Td
(reinfection)Tj
4.5865 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.2026 -1.2983 Td
(same)Tj
2.2563 0 Td
(individual)Tj
4.286 0 Td
(\(multiple)Tj
3.9061 0 Td
(times\))Tj
2.7326 0 Td
(leads)Tj
2.211 0 Td
(to)Tj
1.0261 0 Td
(more)Tj
2.3414 0 Td
(complex)Tj
3.6227 0 Td
(dynamical)Tj
4.3766 0 Td
(behaviour)Tj
4.2406 0 Td
(between)Tj
3.5263 0 Td
(neigh-)Tj
-34.5257 -1.3039 Td
(bouring)Tj
3.4128 0 Td
(nodes)Tj
2.5852 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6576 0 Td
(network)Tj
3.549 0 Td
(and)Tj
1.7291 0 Td
(makes)Tj
2.7553 0 Td
(it)Tj
0.7823 0 Td
(more)Tj
2.3414 0 Td
(difficult)Tj
3.3562 0 Td
(to)Tj
1.0262 0 Td
(generate)Tj
3.6056 0 Td
(tractable)Tj
3.6567 0 Td
(results)Tj
2.8119 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
-32.3487 -1.2982 Td
(When)Tj
2.6872 0 Td
(details)Tj
2.7779 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(complete)Tj
3.8834 0 Td
(network)Tj
3.549 0 Td
(are)Tj
1.4456 0 Td
(available,)Tj
3.8948 0 Td
(and)Tj
1.7291 0 Td
(we)Tj
1.3266 0 Td
(are)Tj
1.4514 0 Td
(dealing)Tj
3.1294 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(particular)Tj
-32.207 -1.2983 Td
(applied)Tj
3.1521 0 Td
(problem,)Tj
3.838 0 Td
(then)Tj
2.0183 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(straightforward)Tj
6.4289 0 Td
(approach)Tj
3.9515 0 Td
(is)Tj
0.8447 0 Td
(to)Tj
1.0261 0 Td
(simulate)Tj
3.6 0 Td
(the)Tj
1.4684 0 Td
(dynamics)Tj
4.0535 0 Td
(of)Tj
1.0148 0 Td
(infec-)Tj
-35.07 -1.3039 Td
(tion)Tj
1.8311 0 Td
(on)Tj
1.2699 0 Td
(the)Tj
1.4627 0 Td
(given)Tj
2.3697 0 Td
(network)Tj
3.5433 0 Td
(\(e.g.)Tj
1.8936 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2529 0 Td
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3889 0 Td
(18)Tj
0 g
(]\).)Tj
2.075 0 Td
(However)Tj
3.8437 0 Td
(in)Tj
1.0262 0 Td
(anything)Tj
3.7587 0 Td
(but)Tj
1.5477 0 Td
(ideal)Tj
2.109 0 Td
(circumstances)Tj
5.896 0 Td
(simu-)Tj
-35.2684 -1.2983 Td
(lation)Tj
2.5171 0 Td
(may)Tj
1.9332 0 Td
(be)Tj
1.1509 0 Td
(problematic.)Tj
5.2554 0 Td
(For)Tj
1.6271 0 Td
(example,)Tj
3.7757 0 Td
(using)Tj
2.3924 0 Td
(simulations)Tj
4.8529 0 Td
(alone:)Tj
2.6078 0 Td
(it)Tj
0.7824 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(difficult)Tj
3.3562 0 Td
(to)Tj
-33.3295 -1.2983 Td
(understand)Tj
4.7848 0 Td
(sensitivity)Tj
4.2236 0 Td
(to)Tj
1.0261 0 Td
(elements)Tj
3.7644 0 Td
(in)Tj
1.0375 0 Td
(network)Tj
3.5489 0 Td
(structure)Tj
3.8211 0 Td
(or)Tj
1.0999 0 Td
(biases)Tj
2.5738 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(way)Tj
1.7972 0 Td
(the)Tj
1.4683 0 Td
(network)Tj
3.549 0 Td
(con-)Tj
-35.1947 -1.3039 Td
(nections)Tj
3.5943 0 Td
(were)Tj
2.1259 0 Td
(sampled;)Tj
3.7758 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(computationally)Tj
6.7464 0 Td
(challenging)Tj
4.8189 0 Td
(to)Tj
1.0261 0 Td
(infer)Tj
2.1146 0 Td
(epidemiological)Tj
6.565 0 Td
(parameters;)Tj
-32.3997 -1.2982 Td
(and)Tj
1.7291 0 Td
(it)Tj
0.788 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(difficult)Tj
3.3505 0 Td
(to)Tj
1.0262 0 Td
(gain)Tj
1.9332 0 Td
(a)Tj
0.6576 0 Td
(robust)Tj
2.7893 0 Td
(understanding)Tj
6.0718 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(causal)Tj
2.6475 0 Td
(determinants)Tj
5.5389 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-33.1084 -1.2983 Td
(observed)Tj
3.7927 0 Td
(dynamics.)Tj
4.2859 0 Td
(Approximations)Tj
6.7805 0 Td
(that)Tj
1.7801 0 Td
(maintain)Tj
3.8381 0 Td
(the)Tj
1.4683 0 Td
(analytic)Tj
3.3279 0 Td
(tractability)Tj
4.5184 0 Td
(of)Tj
1.0148 0 Td
(traditional)Tj
4.422 0 Td
(ODE)Tj
-35.2287 -1.3039 Td
(\(Ordinary)Tj
4.2802 0 Td
(Differential)Tj
4.8132 0 Td
(Equation\))Tj
4.218 0 Td
(models,)Tj
3.3278 0 Td
(but)Tj
1.5534 0 Td
(take)Tj
1.8765 0 Td
(account)Tj
3.3789 0 Td
(of)Tj
1.0148 0 Td
(elements)Tj
3.7644 0 Td
(of)Tj
1.0148 0 Td
(network)Tj
3.5489 0 Td
(structure)Tj
-32.7909 -1.2983 Td
(provide)Tj
3.2881 0 Td
(a)Tj
0.652 0 Td
(possible)Tj
3.4129 0 Td
(solution.)Tj
3.7077 0 Td
(These)Tj
2.5681 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.1203 0 Td
(quite)Tj
2.245 0 Td
(successful)Tj
4.1612 0 Td
(for)Tj
1.389 0 Td
(`one)Tj
1.9219 0 Td
(off')Tj
1.5193 0 Td
(epidemics)Tj
4.252 0 Td
(that)Tj
1.7745 0 Td
(obey)Tj
-35.07 -1.2982 Td
(the)Tj
1.4683 0 Td
(SIR)Tj
1.6554 0 Td
(paradigm,)Tj
4.286 0 Td
(with)Tj
1.9955 0 Td
(notable)Tj
3.1862 0 Td
(advances)Tj
3.8267 0 Td
(including)Tj
4.0422 0 Td
(the)Tj
1.4683 0 Td
(`effective)Tj
3.7361 0 Td
(degree')Tj
3.067 0 Td
(approach)Tj
3.9515 0 Td
(of)Tj
1.0148 0 Td
(Ball)Tj
1.7291 0 Td
(and)Tj
-35.4271 -1.2983 Td
(Neal)Tj
2.0579 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(],)Tj
2.0749 0 Td
(the)Tj
1.474 0 Td
(probability-generating)Tj
9.1899 0 Td
(function)Tj
3.6283 0 Td
(approach)Tj
3.9515 0 Td
(of)Tj
1.0148 0 Td
(Volz)Tj
2.0806 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(])Tj
1.8539 0 Td
(\(and)Tj
2.0692 0 Td
(its)Tj
1.1452 0 Td
(reduction)Tj
4.1159 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
-35.6822 -1.3039 Td
(single)Tj
2.5284 0 Td
(dynamical)Tj
4.3767 0 Td
(equation)Tj
3.736 0 Td
(by)Tj
1.1792 0 Td
(Miller)Tj
2.6646 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(]\))Tj
2.194 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(model)Tj
2.7439 0 Td
(of)Tj
1.0148 0 Td
(Lindquist)Tj
4.0648 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(])Tj
1.8482 0 Td
(\(originally)Tj
4.371 0 Td
(also)Tj
-35.9884 -1.2983 Td
(called)Tj
2.5171 0 Td
(`effective-degree')Tj
6.9392 0 Td
(model,)Tj
2.9707 0 Td
(but)Tj
1.5533 0 Td
(to)Tj
1.0205 0 Td
(which)Tj
2.6532 0 Td
(we)Tj
1.3266 0 Td
(refer)Tj
2.0976 0 Td
(throughout)Tj
4.7792 0 Td
(as)Tj
1.0148 0 Td
(`neighbourhood)Tj
6.6614 0 Td
(model')Tj
2.9593 0 Td
(to)Tj
-36.4929 -1.2983 Td
(avoid)Tj
2.4094 0 Td
(confusion)Tj
4.1952 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(earlier)Tj
2.7553 0 Td
(use)Tj
1.5363 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6725 0 Td
(terminology\).)Tj
5.6919 0 Td
(Such)Tj
2.177 0 Td
(models,)Tj
3.3279 0 Td
(together)Tj
3.5376 0 Td
(with)Tj
1.9955 0 Td
(pairwise)Tj
-33.783 -1.3039 Td
(or)Tj
1.0941 0 Td
(related)Tj
2.948 0 Td
(approximations)Tj
6.5367 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(24)Tj
0 g
(])Tj
1.508 0 Td
(discussed)Tj
4.0025 0 Td
(extensively)Tj
4.5864 0 Td
(in)Tj
1.0375 0 Td
(this)Tj
1.6724 0 Td
(paper,)Tj
2.7099 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.1259 0 Td
(shown)Tj
2.846 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
-35.8863 -1.2982 Td
(exact)Tj
2.262 0 Td
(methods)Tj
3.685 0 Td
(of)Tj
1.0148 0 Td
(calculation)Tj
4.5751 0 Td
(of)Tj
1.0148 0 Td
(marginal)Tj
3.8097 0 Td
(probabilities)Tj
5.1931 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(stochastic)Tj
4.1158 0 Td
(SIR)Tj
1.6611 0 Td
(model)Tj
2.744 0 Td
(for)Tj
1.3833 0 Td
(finite)Tj
-34.316 -1.2983 Td
(explicitly)Tj
3.8267 0 Td
(known)Tj
3.0047 0 Td
(networks)Tj
3.9118 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(].)Tj
3.5433 0 Td
(Such)Tj
2.177 0 Td
(models)Tj
3.1067 0 Td
(can)Tj
1.6214 0 Td
(also)Tj
1.7688 0 Td
(reproduce)Tj
4.3143 0 Td
(the)Tj
1.4684 0 Td
(expected)Tj
3.7247 0 Td
(course)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-36.3172 -1.3039 Td
(stochastic)Tj
4.1215 0 Td
(SIR)Tj
1.6554 0 Td
(model)Tj
2.7439 0 Td
(with)Tj
1.9956 0 Td
(constant)Tj
3.6397 0 Td
(infection)Tj
3.7927 0 Td
(and)Tj
1.7291 0 Td
(recovery)Tj
3.651 0 Td
(rates)Tj
2.109 0 Td
(on)Tj
1.2756 0 Td
(large)Tj
2.16 0 Td
(configuration)Tj
5.6749 0 Td
(model)Tj
-34.5484 -1.2983 Td
(networks)Tj
3.9117 0 Td
(with)Tj
1.9956 0 Td
(with)Tj
1.9956 0 Td
(several)Tj
2.9367 0 Td
(recent)Tj
2.7099 0 Td
(asymptotic)Tj
4.5977 0 Td
(proofs)Tj
2.7723 0 Td
(of)Tj
1.0148 0 Td
(convergence)Tj
5.2327 0 Td
(published)Tj
4.1272 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(].)Tj
3.5433 0 Td
(Much)Tj
-34.8375 -1.2983 Td
(work)Tj
2.279 0 Td
(has)Tj
1.542 0 Td
(also)Tj
1.7688 0 Td
(focussed)Tj
3.6397 0 Td
(on)Tj
1.2756 0 Td
(extending)Tj
4.1839 0 Td
(such)Tj
2.0636 0 Td
(methods)Tj
3.685 0 Td
(to)Tj
1.0205 0 Td
(weighted)Tj
3.8381 0 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(])Tj
1.8538 0 Td
(and)Tj
1.7291 0 Td
(dynamic)Tj
3.6964 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(])Tj
1.8482 0 Td
(net-)Tj
-34.4237 -1.3039 Td
(works,)Tj
2.8629 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0147 0 Td
(to)Tj
1.0262 0 Td
(models)Tj
3.1067 0 Td
(with)Tj
1.9956 0 Td
(arbitrary)Tj
3.7304 0 Td
(duration)Tj
3.702 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(infectious)Tj
4.1329 0 Td
(period)Tj
2.8347 0 Td
([)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(],)Tj
3.5432 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
-35.2627 -1.2982 Td
(common)Tj
3.8437 0 Td
(denominator)Tj
5.4708 0 Td
(that)Tj
1.7802 0 Td
(on)Tj
1.2756 0 Td
(clustered)Tj
3.821 0 Td
(networks)Tj
3.9118 0 Td
(results)Tj
2.812 0 Td
(from)Tj
2.2053 0 Td
(all)Tj
1.1452 0 Td
(approaches)Tj
4.7338 0 Td
(are)Tj
1.4514 0 Td
(only)Tj
-32.4508 -1.2983 Td
(approximate.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 269.8582 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Systematic)Tj
5.0457 0 Td
(Approx)Tj
3.111 0 Td
(imations)Tj
3.8764 0 Td
(to)Tj
1.0418 0 Td
(Susceptib)Tj
4.3157 0 Td
(le-Infectious)Tj
5.2938 0 Td
(-Susceptib)Tj
4.6417 0 Td
(le)Tj
0.9851 0 Td
(Dynami)Tj
3.3307 0 Td
(cs)Tj
1.2048 0 Td
(on)Tj
1.311 0 Td
(Networks)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.13)Tj
4.4859 0 Td
(71/journal.p)Tj
5.1236 0 Td
(cbi.10052)Tj
4.252 0 Td
(96)Tj
2.0906 0 Td
(December)Tj
4.7622 0 Td
(20,)Tj
1.5874 0 Td
(2016)Tj
29.516 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
BT
66.402 0 Td
(18)Tj
ET
Q
endstream
endobj
66 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 68 0 R/Contents 69 0 R/TrimBox[0 0 612 792]>>
endobj
68 0 obj
[70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R]
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref017)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref024)>>
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref038)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref039)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref040)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref040)>>
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref041)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref044)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref045)>>
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.ref046)>>
endobj
80 0 obj
<>/Border[0 0 0]/Dest(Rsec012)>>
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1005296.g001)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rsec002)>>
endobj
69 0 obj
[83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R]
endobj
83 0 obj
<>stream
q
0.83 0.64 0.02 0 k
311.5276 693.2976 m
320.8252 693.2976 l
h
f*
325.1906 693.2976 m
334.5449 693.2976 l
h
f*
548.5039 680.315 m
557.8583 680.315 l
h
f*
562.2236 680.315 m
571.5213 680.315 l
h
f*
290.0409 654.3496 m
299.3953 654.3496 l
h
f*
299.0551 576.3402 m
308.4094 576.3402 l
h
f*
215.7732 446.3433 m
225.2409 446.3433 l
h
f*
230.4 446.3433 m
239.9244 446.3433 l
h
f*
370.9417 420.3213 m
380.4094 420.3213 l
h
f*
384.8882 420.3213 m
394.3559 420.3213 l
h
f*
345.7701 329.3291 m
387.2693 329.3291 l
h
f*
335.9622 238.337 m
355.5213 238.337 l
h
f*
420.3213 94.9039 m
512.2772 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 211.9748 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.013 Tc
0 0 Td
(Despite)Tj
3.1861 0 Td
(all)Tj
1.1168 0 Td
(these)Tj
2.211 0 Td
(successes)Tj
3.8041 0 Td
(concerning)Tj
4.6601 0 Td
(SIR)Tj
1.6271 0 Td
(models)Tj
3.0501 0 Td
(\(or)Tj
1.4116 0 Td
(related)Tj
2.88 0 Td
(models)Tj
3.0557 0 Td
(such)Tj
2.0239 0 Td
(as)Tj
0.9922 0 Td
(SEIR,)Tj
2.4094 0 Td
(which)Tj
-33.6243 -1.3039 Td
(includes)Tj
3.4695 0 Td
(an)Tj
1.1849 0 Td
(exposed)Tj
3.3845 0 Td
(period)Tj
2.778 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7008 0 Td
(24)Tj
0 g
(]\),)Tj
2.0352 0 Td
(the)Tj
1.44 0 Td
(same)Tj
2.2224 0 Td
(is)Tj
0.8277 0 Td
(not)Tj
1.5477 0 Td
(generally)Tj
3.753 0 Td
(true)Tj
1.8028 0 Td
(for)Tj
1.3607 0 Td
(infections)Tj
4.0648 0 Td
(without)Tj
3.2655 0 Td
(long-)Tj
-34.8375 -1.2982 Td
(lasting)Tj
2.7779 0 Td
(immunity,)Tj
4.3653 0 Td
(with)Tj
1.9616 0 Td
(realistic)Tj
3.2314 0 Td
(demographic)Tj
5.4028 0 Td
(turnover)Tj
3.651 0 Td
(or)Tj
1.0829 0 Td
(with)Tj
1.9615 0 Td
(significant)Tj
4.286 0 Td
(viral)Tj
1.9502 0 Td
(mutation)Tj
3.8494 0 Td
([)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7008 0 Td
(39)Tj
0 g
(])Tj
-36.2208 -1.2983 Td
(i.e.,)Tj
2.4547 0 Td
(the)Tj
1.4457 0 Td
(majority)Tj
3.5546 0 Td
(of)Tj
0.9978 0 Td
(pathogens)Tj
4.2179 0 Td
(of)Tj
0.9978 0 Td
(interest.)Tj
3.3562 0 Td
(Here)Tj
2.1713 0 Td
(we)Tj
1.3096 0 Td
(focus)Tj
2.2791 0 Td
(on)Tj
1.2586 0 Td
(STIs)Tj
1.9729 0 Td
(since)Tj
2.1996 0 Td
(the)Tj
1.44 0 Td
(motivation)Tj
4.5354 0 Td
(for)Tj
1.355 0 Td
(use)Tj
-35.5462 -1.2983 Td
(of)Tj
0.9978 0 Td
(a)Tj
0.6406 0 Td
(network)Tj
3.4865 0 Td
(is)Tj
0.8334 0 Td
(strong)Tj
2.7156 0 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(].)Tj
2.0296 0 Td
(These)Tj
2.5228 0 Td
(diseases)Tj
3.3052 0 Td
(are)Tj
1.423 0 Td
(of)Tj
0.9978 0 Td
(major)Tj
2.5625 0 Td
(public)Tj
2.6532 0 Td
(health)Tj
2.6248 0 Td
(importance)Tj
4.7395 0 Td
(and)Tj
1.7065 0 Td
(the)Tj
1.44 0 Td
(appro-)Tj
-34.6788 -1.3039 Td
(priate)Tj
2.4774 0 Td
(modelling)Tj
4.1896 0 Td
(framework)Tj
4.5354 0 Td
(\(the)Tj
1.7688 0 Td
(SIS)Tj
1.4853 0 Td
(model)Tj
2.6986 0 Td
(on)Tj
1.2586 0 Td
(a)Tj
0.6463 0 Td
(network,)Tj
3.702 0 Td
(also)Tj
1.7348 0 Td
(called)Tj
2.4661 0 Td
(the)Tj
1.44 0 Td
(`contact)Tj
3.3052 0 Td
(process')Tj
3.3278 0 Td
(and)Tj
-35.0359 -1.2982 Td
(frequently)Tj
4.2179 0 Td
(considered)Tj
4.5127 0 Td
(in)Tj
1.0148 0 Td
(theoretical)Tj
4.3426 0 Td
(studies\))Tj
3.2542 0 Td
(is)Tj
0.8277 0 Td
(the)Tj
1.4457 0 Td
(most)Tj
2.1656 0 Td
(challenging)Tj
4.7168 0 Td
(for)Tj
1.3607 0 Td
(approximation)Tj
6.0547 0 Td
(models)Tj
-33.9134 -1.2983 Td
(to)Tj
1.0035 0 Td
(capture.)Tj
3.3731 0 Td
(To)Tj
1.3209 0 Td
(fully)Tj
1.9333 0 Td
(predict)Tj
2.9877 0 Td
(the)Tj
1.4399 0 Td
(dynamics)Tj
3.9855 0 Td
(and)Tj
1.7065 0 Td
(hence)Tj
2.5171 0 Td
(the)Tj
1.4457 0 Td
(impact)Tj
2.9253 0 Td
(of)Tj
0.9978 0 Td
(control)Tj
3.0557 0 Td
(on)Tj
1.2586 0 Td
(a)Tj
0.6463 0 Td
(range)Tj
2.4151 0 Td
(of)Tj
0.9978 0 Td
(sexually)Tj
-34.0098 -1.3039 Td
(transmitted)Tj
4.7678 0 Td
(infections)Tj
4.0648 0 Td
(requires)Tj
3.3959 0 Td
(mathematical)Tj
5.5389 0 Td
(models)Tj
3.05 0 Td
(that)Tj
1.7462 0 Td
(can)Tj
1.5987 0 Td
(account)Tj
3.3165 0 Td
(for)Tj
1.3606 0 Td
(both)Tj
2.024 0 Td
(network)Tj
3.4866 0 Td
(struc-)Tj
-34.35 -1.2983 Td
(ture)Tj
1.8028 0 Td
(of)Tj
0.9977 0 Td
(sexual)Tj
2.6249 0 Td
(partnership)Tj
4.7565 0 Td
(and)Tj
1.7008 0 Td
(the)Tj
1.4457 0 Td
(complications)Tj
5.7202 0 Td
(that)Tj
1.7462 0 Td
(arise)Tj
2.0296 0 Td
(from)Tj
2.1713 0 Td
(reinfection)Tj
4.4844 0 Td
(that)Tj
1.7461 0 Td
(is)Tj
0.8277 0 Td
(associated)Tj
-32.0539 -1.2983 Td
(with)Tj
1.9502 0 Td
(SIS-type)Tj
3.4752 0 Td
(behaviour)Tj
4.1499 0 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(].)Tj
2.0183 0 Td
(Here)Tj
2.16 0 Td
(we)Tj
1.3039 0 Td
(consider)Tj
3.5659 0 Td
(three)Tj
2.2111 0 Td
(distinct)Tj
3.1294 0 Td
(approaches)Tj
4.6374 0 Td
(to)Tj
0.9978 0 Td
(capture)Tj
3.1408 0 Td
(the)Tj
1.4343 0 Td
(dynamic)Tj
-34.1742 -1.3039 Td
(build-up)Tj
3.6169 0 Td
(of)Tj
0.9978 0 Td
(correlations)Tj
4.8699 0 Td
(between)Tj
3.4639 0 Td
(nearby)Tj
2.9083 0 Td
(individuals)Tj
4.5468 0 Td
(on)Tj
1.2586 0 Td
(the)Tj
1.4456 0 Td
(networkeach)Tj
6.1738 0 Td
(approximation)Tj
-29.2816 -1.2982 Td
(methodology)Tj
5.4027 0 Td
(has)Tj
1.5081 0 Td
(an)Tj
1.1848 0 Td
(associated)Tj
4.1613 0 Td
(integer)Tj
2.948 0 Td
(that)Tj
1.7404 0 Td
(can)Tj
1.5988 0 Td
(be)Tj
1.1282 0 Td
(increased)Tj
3.9117 0 Td
(to)Tj
1.0035 0 Td
(achieve)Tj
3.1124 0 Td
(greater)Tj
2.9367 0 Td
(levels)Tj
2.3187 0 Td
(of)Tj
0.9921 0 Td
(accuracy.)Tj
-33.9474 -1.2983 Td
(We)Tj
1.5873 0 Td
(stress,)Tj
2.5625 0 Td
(however,)Tj
3.7644 0 Td
(that)Tj
1.7405 0 Td
(our)Tj
1.5987 0 Td
(approach)Tj
3.8834 0 Td
(does)Tj
2.0013 0 Td
(not)Tj
1.5477 0 Td
(rely)Tj
1.6781 0 Td
(on)Tj
1.2586 0 Td
(special)Tj
2.8289 0 Td
(features)Tj
3.2769 0 Td
(of)Tj
0.9921 0 Td
(the)Tj
1.4456 0 Td
(SIS)Tj
1.4854 0 Td
(model)Tj
2.6986 0 Td
(but)Tj
1.525 0 Td
(can)Tj
-35.875 -1.3039 Td
(be)Tj
1.1339 0 Td
(applied)Tj
3.0896 0 Td
(to)Tj
1.0035 0 Td
(the)Tj
1.4457 0 Td
(full)Tj
1.491 0 Td
(spectrum)Tj
3.8891 0 Td
(of)Tj
0.9978 0 Td
(disease-dynamics)Tj
7.0582 0 Td
(models)Tj
3.05 0 Td
(used)Tj
2.024 0 Td
(to)Tj
1.0091 0 Td
(inform)Tj
2.965 0 Td
(applied)Tj
3.0954 0 Td
(epidemiology)Tj
-32.2523 -1.2983 Td
(and)Tj
1.7007 0 Td
(public)Tj
2.6532 0 Td
(health)Tj
2.6249 0 Td
(\(including)Tj
4.2916 0 Td
(those)Tj
2.2961 0 Td
(with)Tj
1.9615 0 Td
(short-term)Tj
4.4561 0 Td
(immunity)Tj
4.1499 0 Td
(and)Tj
1.7064 0 Td
(hence)Tj
2.5172 0 Td
(SIRS-type)Tj
4.0988 0 Td
(dynamics\).)Tj
-0.005 Tc
-31.2602 -1.2982 Td
(Although)Tj
3.9968 0 Td
(the)Tj
1.4683 0 Td
(long-term)Tj
4.2406 0 Td
(aim)Tj
1.7405 0 Td
(is)Tj
0.8447 0 Td
(to)Tj
1.0205 0 Td
(utilise)Tj
2.6078 0 Td
(such)Tj
2.0523 0 Td
(approximation)Tj
6.1625 0 Td
(techniques)Tj
4.5184 0 Td
(to)Tj
1.0204 0 Td
(gain)Tj
1.9333 0 Td
(a)Tj
0.6519 0 Td
(clear)Tj
-33.4542 -1.2983 Td
(understanding)Tj
6.0547 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4627 0 Td
(dynamics)Tj
4.0535 0 Td
(of)Tj
1.0091 0 Td
(STIs)Tj
2.0069 0 Td
(\(as)Tj
1.3493 0 Td
(well)Tj
1.8142 0 Td
(as)Tj
1.0148 0 Td
(other)Tj
2.3414 0 Td
(infections)Tj
4.1442 0 Td
(that)Tj
1.7745 0 Td
(confer)Tj
2.7779 0 Td
(short-duration)Tj
-30.818 -1.3039 Td
(immunity\))Tj
4.5467 0 Td
(on)Tj
1.2642 0 Td
(realistic)Tj
3.2995 0 Td
(networks,)Tj
4.1216 0 Td
(we)Tj
1.3152 0 Td
(focus)Tj
2.3188 0 Td
(this)Tj
1.6611 0 Td
(paper)Tj
2.4718 0 Td
(on)Tj
1.2699 0 Td
(understanding)Tj
6.0491 0 Td
(when)Tj
2.3924 0 Td
(simple)Tj
2.8403 0 Td
(modelling)Tj
-33.5506 -1.2983 Td
(techniques)Tj
4.5127 0 Td
(fail.)Tj
1.6724 0 Td
(One)Tj
1.9332 0 Td
(occasion)Tj
3.6794 0 Td
(when)Tj
2.3981 0 Td
(simple)Tj
2.8403 0 Td
(approaches)Tj
4.7224 0 Td
(fail)Tj
1.4514 0 Td
(is)Tj
0.839 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4627 0 Td
(case)Tj
1.8538 0 Td
(of)Tj
1.0092 0 Td
(extreme)Tj
3.4355 0 Td
(heterogene-)Tj
-32.8419 -1.2983 Td
(ity)Tj
1.2358 0 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(].)Tj
3.5377 0 Td
(Although)Tj
3.9968 0 Td
(risk-structure)Tj
5.6522 0 Td
(\(or)Tj
1.44 0 Td
(heterogeneity)Tj
5.6353 0 Td
(in)Tj
1.0374 0 Td
(network)Tj
3.5433 0 Td
(structure\))Tj
4.1499 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.652 0 Td
(highly)Tj
2.7042 0 Td
(impor-)Tj
-34.4293 -1.3039 Td
(tant)Tj
1.7914 0 Td
(aspect)Tj
2.6759 0 Td
(of)Tj
1.0091 0 Td
(modelling)Tj
4.2633 0 Td
(STIespecially)Tj
6.3553 0 Td
(in)Tj
1.0318 0 Td
(terms)Tj
2.4888 0 Td
(of)Tj
1.0148 0 Td
(defining)Tj
3.5489 0 Td
(individual)Tj
4.2746 0 Td
(riskwe)Tj
3.7417 0 Td
(argue)Tj
2.4378 0 Td
(that)Tj
-34.6334 -1.2982 Td
(many)Tj
2.4717 0 Td
(studies)Tj
2.9821 0 Td
(have)Tj
2.0522 0 Td
(focussed)Tj
3.634 0 Td
(on)Tj
1.2699 0 Td
(this)Tj
1.6725 0 Td
(aspect)Tj
2.6702 0 Td
([)Tj
0.83 0.64 0.02 0 k
(45)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(46)Tj
0 g
(])Tj
1.508 0 Td
(and)Tj
1.7291 0 Td
(that)Tj
1.7745 0 Td
(it)Tj
0.7824 0 Td
(is)Tj
0.8447 0 Td
(usually)Tj
3.0104 0 Td
(possible)Tj
3.4015 0 Td
(to)Tj
1.0261 0 Td
(capture)Tj
3.2088 0 Td
(epi-)Tj
-35.7729 -1.2983 Td
(demiological)Tj
5.3404 0 Td
(effects)Tj
2.7212 0 Td
(of)Tj
1.0091 0 Td
(population)Tj
4.5808 0 Td
(heterogeneity)Tj
5.6409 0 Td
(by)Tj
1.1792 0 Td
(modestly)Tj
3.8494 0 Td
(increasing)Tj
4.32 0 Td
(the)Tj
1.4684 0 Td
(system's)Tj
3.5036 0 Td
(dimen-)Tj
-33.613 -1.3039 Td
(sion)Tj
1.8991 0 Td
(through)Tj
3.4356 0 Td
(the)Tj
1.4683 0 Td
(introduction)Tj
5.3008 0 Td
(of)Tj
1.0148 0 Td
(multiple)Tj
3.5546 0 Td
(risk-groups)Tj
4.8075 0 Td
(\(e.g.)Tj
1.8936 0 Td
(low-)Tj
2.0012 0 Td
(and)Tj
1.7291 0 Td
(high-risk)Tj
3.8438 0 Td
(behaviour\).)Tj
-0.004 Tc
-29.7522 -1.2983 Td
(In)Tj
1.1111 0 Td
(contrast)Tj
3.4639 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(heterogeneous)Tj
6.0264 0 Td
(case,)Tj
2.0863 0 Td
(the)Tj
1.4684 0 Td
(impact)Tj
2.982 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(limited)Tj
3.0728 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(contacts)Tj
3.515 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
-35.2457 -1.2983 Td
(build-up)Tj
3.6906 0 Td
(of)Tj
1.0148 0 Td
(dynamical)Tj
4.3767 0 Td
(correlations)Tj
4.9776 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(state)Tj
2.0353 0 Td
(of)Tj
1.0148 0 Td
(neighbouring)Tj
5.6465 0 Td
(nodes)Tj
2.5852 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(less)Tj
1.61 0 Td
(studied)Tj
3.1521 0 Td
(issue)Tj
-34.1118 -1.2982 Td
(that)Tj
1.7744 0 Td
(presents)Tj
3.5263 0 Td
(deep)Tj
2.1146 0 Td
(conceptual)Tj
4.5694 0 Td
(challenges,)Tj
4.5411 0 Td
(especially)Tj
4.0195 0 Td
(for)Tj
1.3833 0 Td
(SIS)Tj
1.5137 0 Td
(dynamics.)Tj
4.2803 0 Td
(We)Tj
1.6101 0 Td
(therefore)Tj
3.8551 0 Td
(focus)Tj
2.3244 0 Td
(on)Tj
-35.5122 -1.3039 Td
(developing)Tj
4.5977 0 Td
(a)Tj
0.6576 0 Td
(better)Tj
2.5399 0 Td
(understanding)Tj
6.0717 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6725 0 Td
(problem)Tj
3.6113 0 Td
(by)Tj
1.1792 0 Td
(ignoring)Tj
3.6623 0 Td
(many)Tj
2.4775 0 Td
(realistic)Tj
3.3108 0 Td
(features)Tj
3.3506 0 Td
(of)Tj
1.0148 0 Td
(STIs)Tj
-35.1607 -1.2983 Td
(\(we)Tj
1.6667 0 Td
(briefly)Tj
2.7779 0 Td
(comment)Tj
4.0592 0 Td
(on)Tj
1.2756 0 Td
(them)Tj
2.2904 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
0.83 0.64 0.02 0 k
1.4683 0 Td
(discussion)Tj
0 g
(\))Tj
4.7111 0 Td
(and)Tj
1.7292 0 Td
(considering)Tj
4.9322 0 Td
(the)Tj
1.4684 0 Td
(idealised)Tj
3.6963 0 Td
(case)Tj
1.8652 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(homo-)Tj
-34.6448 -1.2983 Td
(geneous)Tj
3.4752 0 Td
(degree)Tj
2.8573 0 Td
(or)Tj
1.0942 0 Td
(`)Tj
/F10 1 Tf
[()]TJ
/F5 1 Tf
(-regular')Tj
4.3143 0 Td
(networks)Tj
3.9118 0 Td
(with)Tj
1.9955 0 Td
(low)Tj
1.6611 0 Td
(connectivity)Tj
5.1364 0 Td
(and)Tj
1.7291 0 Td
(hence)Tj
2.5682 0 Td
(greater)Tj
3.0047 0 Td
(importance)Tj
4.8302 0 Td
(of)Tj
-36.578 -1.3039 Td
(the)Tj
1.4683 0 Td
(link)Tj
1.7801 0 Td
(with)Tj
1.9956 0 Td
(each)Tj
2.0296 0 Td
(contact)Tj
3.1521 0 Td
(\(in)Tj
1.3776 0 Td
(particular)Tj
/F10 1 Tf
4.1102 0 Td
[()]TJ
/F5 1 Tf
0.686 0 Td
(=)Tj
0.7994 0 Td
(3)Tj
0.6916 0 Td
(and)Tj
/F10 1 Tf
1.7348 0 Td
[()]TJ
/F5 1 Tf
0.686 0 Td
(=)Tj
0.7994 0 Td
(2\).)Tj
1.2585 0 Td
(In)Tj
1.1112 0 Td
(these)Tj
2.2507 0 Td
(remarkably)Tj
4.7792 0 Td
(simple)Tj
2.8573 0 Td
(networks,)Tj
-33.5676 -1.2982 Td
(the)Tj
1.4683 0 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(local)Tj
2.0749 0 Td
(correlations)Tj
4.9776 0 Td
(are)Tj
1.4514 0 Td
(at)Tj
0.9524 0 Td
(their)Tj
2.109 0 Td
(strongest)Tj
3.8494 0 Td
(and)Tj
1.7348 0 Td
(are)Tj
1.4456 0 Td
(not)Tj
1.5761 0 Td
(masked)Tj
3.2825 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(impact)Tj
2.9821 0 Td
(of)Tj
-34.2933 -1.2983 Td
(degree)Tj
2.8516 0 Td
(heterogeneity.)Tj
5.879 0 Td
(To)Tj
1.3379 0 Td
(illustrate)Tj
3.6964 0 Td
(this)Tj
1.6724 0 Td
(concept)Tj
3.3619 0 Td
(we)Tj
1.3266 0 Td
(compare)Tj
3.719 0 Td
(simple)Tj
2.8517 0 Td
(risk-structured)Tj
6.1965 0 Td
(mean-field)Tj
-32.893 -1.3039 Td
(\(random-mixing\))Tj
7.2906 0 Td
(models)Tj
3.1068 0 Td
(\(which)Tj
2.9876 0 Td
(account)Tj
3.3846 0 Td
(for)Tj
1.3833 0 Td
(degree)Tj
2.8573 0 Td
(heterogeneity)Tj
5.6522 0 Td
(within)Tj
2.812 0 Td
(the)Tj
1.4683 0 Td
(network)Tj
3.549 0 Td
(but)Tj
1.5534 0 Td
(not)Tj
-36.0451 -1.2983 Td
(correlations)Tj
4.9775 0 Td
(that)Tj
1.7802 0 Td
(develop)Tj
3.3165 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(contact)Tj
3.1521 0 Td
(structure\))Tj
4.1613 0 Td
(with)Tj
2.0012 0 Td
(results)Tj
2.8063 0 Td
(from)Tj
2.2053 0 Td
(stochastic)Tj
4.1216 0 Td
(network)Tj
3.5489 0 Td
(simu-)Tj
-34.7978 -1.2983 Td
(lations)Tj
2.8799 0 Td
(of)Tj
1.0148 0 Td
(SIS)Tj
1.5137 0 Td
(infection)Tj
3.7927 0 Td
(dynamics)Tj
4.0536 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(This)Tj
1.9899 0 Td
(example)Tj
3.5489 0 Td
(demonstrates)Tj
5.5956 0 Td
(that)Tj
1.7745 0 Td
(when)Tj
2.4037 0 Td
(either)Tj
2.5342 0 Td
(the)Tj
-34.1799 -1.3039 Td
(mean)Tj
2.4434 0 Td
(degree)Tj
2.8573 0 Td
(or)Tj
1.0942 0 Td
(the)Tj
1.474 0 Td
(variance)Tj
3.5773 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(degree)Tj
2.8573 0 Td
(distribution)Tj
4.9663 0 Td
(increases,)Tj
4.0592 0 Td
(so)Tj
1.0885 0 Td
(the)Tj
1.4683 0 Td
(standard)Tj
3.7247 0 Td
(risk-struc-)Tj
-32.1106 -1.2982 Td
(tured)Tj
2.3697 0 Td
(ODE)Tj
2.2677 0 Td
(model)Tj
2.7439 0 Td
(provides)Tj
3.651 0 Td
(a)Tj
0.6576 0 Td
(better)Tj
2.5399 0 Td
(fit)Tj
1.0715 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(simulated)Tj
4.1272 0 Td
(dynamics.)Tj
4.2803 0 Td
(The)Tj
1.7859 0 Td
(agreement)Tj
4.4276 0 Td
(between)Tj
-32.4167 -1.2983 Td
(these)Tj
2.2506 0 Td
(simple)Tj
2.8573 0 Td
(models)Tj
3.1068 0 Td
(and)Tj
1.7291 0 Td
(simulations)Tj
4.8586 0 Td
(is)Tj
0.8447 0 Td
(worst)Tj
2.4434 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6577 0 Td
(homogeneous)Tj
5.8336 0 Td
(degree)Tj
2.8573 0 Td
(3)Tj
0.6974 0 Td
(network)Tj
3.5489 0 Td
(and)Tj
1.7291 0 Td
(hence)Tj
-34.7978 -1.2983 Td
(it)Tj
0.7824 0 Td
(is)Tj
0.8503 0 Td
(this)Tj
1.6724 0 Td
(test)Tj
1.6044 0 Td
(scenario)Tj
3.5546 0 Td
(we)Tj
1.3266 0 Td
(predominantly)Tj
6.1852 0 Td
(consider)Tj
3.651 0 Td
(throughout)Tj
4.7735 0 Td
(this)Tj
1.6781 0 Td
(paper.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 156.9826 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F0 1 Tf
0 -1.4976 Td
(Discussion)Tj
4.9937 0 Td
(of)Tj
1.0441 0 Td
(models)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 122.0031 cm
BT
/F5 1 Tf
1 TL
-0.005 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(this)Tj
1.6724 0 Td
(work,)Tj
2.4945 0 Td
(simulation)Tj
4.49 0 Td
(models)Tj
3.0954 0 Td
(and)Tj
1.7291 0 Td
(traditional)Tj
4.4107 0 Td
(mean-field)Tj
4.5354 0 Td
(approximation)Tj
6.1625 0 Td
(models)Tj
3.1011 0 Td
(\(that)Tj
2.1146 0 Td
(ignore)Tj
-34.9112 -1.2982 Td
(network)Tj
3.5432 0 Td
(structure\))Tj
4.1499 0 Td
(represent)Tj
3.9515 0 Td
(two)Tj
1.7064 0 Td
(extremes)Tj
3.7984 0 Td
(in)Tj
1.0319 0 Td
(terms)Tj
2.4888 0 Td
(of)Tj
1.0148 0 Td
(analytic)Tj
3.3165 0 Td
(tractability)Tj
4.507 0 Td
(and)Tj
1.7291 0 Td
(computational)Tj
-31.2375 -1.3039 Td
(efficiency.)Tj
4.2406 0 Td
(Two)Tj
2.0182 0 Td
(approximate)Tj
5.2667 0 Td
(models)Tj
3.0955 0 Td
(for)Tj
1.3833 0 Td
(SIS-dynamics)Tj
5.6862 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Materials)Tj
4.2803 0 Td
(and)Tj
1.7291 0 Td
(Methods)Tj
0 g
(\))Tj
4.0876 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
-33.8454 -1.2983 Td
(developed)Tj
4.2632 0 Td
(that)Tj
1.7745 0 Td
(lie)Tj
1.1509 0 Td
(between)Tj
3.5206 0 Td
(these)Tj
2.2507 0 Td
(extremes:)Tj
/F10 1 Tf
4.0251 0 Td
[()4()16()12()-20()-13()-4()-3()]TJ
/F5 1 Tf
3.4526 0 Td
(and)Tj
/F10 1 Tf
1.7235 0 Td
[( )6()2()10(\n)-2()17()4(\r)11()12()8()6(\r)4(\r)4()]TJ
/F5 1 Tf
6.0774 0 Td
(approximations.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 269.8582 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Systematic)Tj
5.0457 0 Td
(Approx)Tj
3.111 0 Td
(imations)Tj
3.8764 0 Td
(to)Tj
1.0418 0 Td
(Susceptib)Tj
4.3157 0 Td
(le-Infectious)Tj
5.2938 0 Td
(-Susceptib)Tj
4.6417 0 Td
(le)Tj
0.9851 0 Td
(Dynami)Tj
3.3307 0 Td
(cs)Tj
1.2048 0 Td
(on)Tj
1.311 0 Td
(Networks)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.13)Tj
4.4859 0 Td
(71/journal.p)Tj
5.1236 0 Td
(cbi.10052)Tj
4.252 0 Td
(96)Tj
2.0906 0 Td
(December)Tj
4.7622 0 Td
(20,)Tj
1.5874 0 Td
(2016)Tj
29.516 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
endstream
endobj
92 0 obj
<>stream
endstream
endobj
93 0 obj
<>stream
endstream
endobj
94 0 obj
<>stream
endstream
endobj
95 0 obj
<>stream
endstream
endobj
96 0 obj
<>stream
endstream
endobj
97 0 obj
<>stream
BT
66.402 0 Td
(18)Tj
ET
Q
endstream
endobj
98 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 109 0 R/Contents 110 0 R/TrimBox[0 0 612 792]>>
endobj
101 0 obj
<>
endobj
111 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
11 beginbfchar
<0024><0044>
<0025><0045>
<0029><0049>
<002F><004F>
<0045><0065>
<004B><006B>
<004E><006E>
<004F><006F>
<0052><0072>
<0054><0074>
<0057><0077>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
112 0 obj
<>/FontDescriptor 113 0 R/DW 278/W[36[704 611] 41[259] 47[759] 69[537] 75[481] 78[556 574] 82[333] 84[315] 87[759]]>>
endobj
113 0 obj
<>
endobj
114 0 obj
<>stream
LTSH COS/2