Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
UNSPECIFIED. (2004) Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nature, 7 (5). pp. 493-494. ISSN 1097-6256Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/nn1226
The hypothalamic arcuate nucleus (ARC) integrates and responds to satiety and hunger signals and forms the origins of the central neural response to perturbations in energy balance. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. We propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Journal or Publication Title:||Nature|
|Publisher:||NATURE PUBLISHING GROUP|
|Number of Pages:||2|
|Page Range:||pp. 493-494|
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