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Current practices in patient-reported outcome (PRO) data collection in clinical trials : a cross-sectional survey of UK trial staff and management
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Kyte, Derek, Ives, Jonathan, Draper, Heather and Calvert, Melanie (2016) Current practices in patient-reported outcome (PRO) data collection in clinical trials : a cross-sectional survey of UK trial staff and management. BMJ Open, 6 (10). e012281. doi:10.1136/bmjopen-2016-012281 ISSN 2044-6055.
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Official URL: http://dx.doi.org/10.1136/bmjopen-2016-012281
Abstract
Objectives
Patient-reported outcome measures (PROMs) collected in clinical trials should be administered in a standardised way across sites and routinely screened for avoidable missing data in order to maximise data quality/minimise risk of bias. Recent qualitative findings, however, have raised concerns about the consistency of PROM administration in UK trials. The purpose of this study was to determine the generalisability of these findings across the wider community of trial personnel.
Design
Online cross-sectional survey.
Setting
Participants were recruited from 55 UK Clinical Research Collaboration Registered Clinical Trials Units and 19 Comprehensive Local Research Networks.
Participants
Research nurses, data managers/coordinators, trial managers and chief/principal investigators involved in clinical trials collecting PROMs.
Analysis
We undertook descriptive analyses of the quantitative data and directed thematic analysis of free-text comments. Factors associated with the management of missing PRO data were explored using logistic regression.
Results
Survey data from 767 respondents supported the generalisability of qualitative study findings, suggesting inconsistencies in PROM administration with regard to: the level of assistance given to trial participants; the timing of PROM completion in relation to the clinical consultation; and the management of missing data. Having ≥10 years experience in a research role was significantly associated with the appropriate management of missing PROM data (OR 2.26 (95% CI 1.06 to 4.82), p=0.035). There was a consensus that more PROM guidance was needed in future trials and agreement between professional groups about the necessary components.
Conclusions
There are inconsistencies in the way PROMs are administered by trial staff. Such inconsistencies may reduce the quality of data and have the potential to introduce bias. There is a need for improved guidance in future trials that support trial personnel in conducting optimal PROM data collection to inform patient care.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | BMJ Open | ||||||||
| Publisher: | BMJ | ||||||||
| ISSN: | 2044-6055 | ||||||||
| Official Date: | 1 October 2016 | ||||||||
| Dates: |
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| Volume: | 6 | ||||||||
| Number: | 10 | ||||||||
| Article Number: | e012281 | ||||||||
| DOI: | 10.1136/bmjopen-2016-012281 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) |
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