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The K+ channel TASK1 modulates -adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway
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Pisani, D. F., Beranger, G. E., Corinus, A., Giroud, M., Ghandour, R. A., Altirriba, J., Chambard, J.-C., Mazure, N. M., Bendahhou, S., Duranton, C., Michiels, J.-F., Frontini, A., Rohner-Jeanrenaud, F., Cinti, S., Christian, Mark, Barhanin, J. and Amri, E.-Z. (2016) The K+ channel TASK1 modulates -adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway. The FASEB Journal, 30 (2). pp. 909-922. doi:10.1096/fj.15-277475 ISSN 0892-6638.
An open access version can be found in:
Official URL: http://dx.doi.org/10.1096/fj.15-277475
Abstract
Brown adipose tissue (BAT) is essential for adaptive thermogenesis and dissipation of caloric excess through the activity of uncoupling protein (UCP)-1. BAT in humans is of great interest for the treatment of obesity and related diseases. In this study, the expression of Twik-related acid-sensitive K+ channel (TASK)-1 [a pH-sensitive potassium channel encoded by the potassium channel, 2-pore domain, subfamily K, member 3 (Kcnk3) gene] correlated highly with Ucp1 expression in obese and cold-exposed mice. In addition, Task1-null mice, compared with their controls, became overweight, mainly because of an increase in white adipose tissue mass and BAT whitening. Task1−/−-mouse–derived brown adipocytes, compared with wild-type mouse–derived brown adipocytes, displayed an impaired β3-adrenergic receptor response that was characterized by a decrease in oxygen consumption, Ucp1 expression, and lipolysis. This phenotype was thought to be caused by an exacerbation of mineralocorticoid receptor (MR) signaling, given that it was mimicked by corticoids and reversed by an MR inhibitor. We concluded that the K+ channel TASK1 controls the thermogenic activity in brown adipocytes through modulation of β-adrenergic receptor signaling.—Pisani, D. F., Beranger, G. E., Corinus, A., Giroud, M., Ghandour, R. A., Altirriba, J., Chambard, J.-C., Mazure, N. M., Bendahhou, S., Duranton, C., Michiels, J.-F., Frontini, A., Rohner-Jeanrenaud, F., Cinti, S., Christian, M., Barhanin, J., Amri, E.-Z. The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | The FASEB Journal | ||||||||
Publisher: | Federation of American Societies for Experimental Biology | ||||||||
ISSN: | 0892-6638 | ||||||||
Official Date: | February 2016 | ||||||||
Dates: |
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Volume: | 30 | ||||||||
Number: | 2 | ||||||||
Page Range: | pp. 909-922 | ||||||||
DOI: | 10.1096/fj.15-277475 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Open Access Version: |
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