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Mph1/MPS1 checks in at the kinetochore
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Hervas-Aguilar, Maria-America and Millar, Jonathan B. A. (2016) Mph1/MPS1 checks in at the kinetochore. Cell Cycle, 15 (10). pp. 1313-1314. doi:10.1080/15384101.2016.1159888 ISSN 1538-4101.
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Official URL: http://dx.doi.org/10.1080/15384101.2016.1159888
Abstract
The kinetochore is the major attachment site between chromosomes and microtubules during mitosis but also acts as the platform for the action of a surveillance system, known as the spindle assembly checkpoint (SAC), which ensures sister chromatids do not separate until all chromosomes are correctly bi-oriented1 London N, Biggins S. Signaling dynamics in the spindle checkpoint response. Nat Rev Mol Cell Biol 2014; 15:736-47; PMID:25303117; http://dx.doi.org/10.1038/nrm3888
[CrossRef], [PubMed], [Web of Science ®]
. Components of the SAC include the Mad1, Mad2, BubR1 (Mad3) and Bub3 proteins and the Bub1, Mps1 (Mph1) and Aurora-B kinases. When individual kinetochores are not bound to spindle microtubules checkpoint proteins are recruited to the unattached kinetochore and the SAC is activated. Kinetochore association of Mad2 induces a conformational change which allows it to bind Mad3 and Cdc20 to form a potent inhibitor, the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex/cyclosome (APC/C), a specialized E3 ubiquitin ligase. When the checkpoint is satisfied the spindle checkpoint signal is silenced and the Cdc20-APC/C is activated. This triggers the poly-ubiquitination of securin and cyclin, which allows the dissolution of sister chromatid cohesion and mitotic progression1 London N, Biggins S. Signaling dynamics in the spindle checkpoint response. Nat Rev Mol Cell Biol 2014; 15:736-47; PMID:25303117; http://dx.doi.org/10.1038/nrm3888
[CrossRef], [PubMed], [Web of Science ®]
. This is a crucial step during the cell cycle as it ensures accurate segregation of sister chromatids to daughter cells.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Cell Cycle | ||||||||
| Publisher: | Landes Bioscience | ||||||||
| ISSN: | 1538-4101 | ||||||||
| Official Date: | 12 April 2016 | ||||||||
| Dates: |
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| Volume: | 15 | ||||||||
| Number: | 10 | ||||||||
| Page Range: | pp. 1313-1314 | ||||||||
| DOI: | 10.1080/15384101.2016.1159888 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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