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Super-duper resolution imaging of mitotic microtubules
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Royle, Stephen J. (2015) Super-duper resolution imaging of mitotic microtubules. Nature Reviews Molecular Cell Biology, 16 (2). p. 67. doi:10.1038/nrm3937 ISSN 1471-0072.
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Official URL: http://dx.doi.org/10.1038/nrm3937
Abstract
There is a lot of excitement about super-resolution imaging in cell biology and how we can integrate image analysis and computer modelling to quantify our data. The papers I am highlighting describe nanometre-scale imaging of microtubules within the mitotic spindle in three dimensions. They used computer processing and spatial statistics to model the organization of these microtubules; cutting-edge stuff, but the papers are more than 20 years old! The McIntosh group used electron microscopy and computational image processing to analyse serial sections of mitotic rat-kangaroo kidney epithelial cells. Spindles at different mitotic stages were reconstructed, enabling the investigators to trace the course of individual microtubules....
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Nature Reviews Molecular Cell Biology | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1471-0072 | ||||
Official Date: | 5 January 2015 | ||||
Dates: |
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Volume: | 16 | ||||
Number: | 2 | ||||
Page Range: | p. 67 | ||||
DOI: | 10.1038/nrm3937 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
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