The Library
A multistudy analysis investigating systematic differences in cardiovascular trial results between Europe and Asia
Tools
Hartley, Louise C., Girling, Alan J., Bowater, Russell J. and Lilford, Richard (2014) A multistudy analysis investigating systematic differences in cardiovascular trial results between Europe and Asia. Journal of Epidemiology and Community Health, 69 (4). pp. 397-404. doi:10.1136/jech-2013-203646 ISSN 0143-005X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1136/jech-2013-203646
Abstract
Objective: To assess whether there are differences in the results of cardiovascular trials between Europe and Asia using data from an extensive collection of randomised controlled trials.
Study design and setting: All meta-analyses containing randomised controlled trials (RCT's) for the treatment or prevention of cardiovascular diseases were searched for in The Cochrane Library (2000–2008) and MEDLINE (2005–2008). Analysis was then conducted within and over each meta-analysis which satisfied given criteria. Separate estimates of treatment effect were calculated for Europe and Asia in each meta-analysis and then compared. Estimates of a common inter-continental difference over all meta-analyses were also calculated and meta-regression was performed. This was performed for both fatal and non-fatal end points.
Results: The literature search identified 59 meta-analyses that satisfied the inclusion criteria. After exclusion, the number of meta-analyses reporting greater effect sizes in Asia than in Europe was significantly more than would be expected by chance (fatal 12/14, p=0.013; non-fatal 23/32, p=0.020).
Conclusions: This study provides some evidence that for cardiovascular interventions treatment effect estimation differs between Europe and Asia, with respect to both fatal and non-fatal end points.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||
Library of Congress Subject Headings (LCSH): | Cardiovascular system -- Diseases -- Europe, Cardiovascular system -- Diseases -- Asia, Systematic reviews (Medical research) | ||||||||
Journal or Publication Title: | Journal of Epidemiology and Community Health | ||||||||
Publisher: | B M J Group | ||||||||
ISSN: | 0143-005X | ||||||||
Official Date: | 4 December 2014 | ||||||||
Dates: |
|
||||||||
Volume: | 69 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 397-404 | ||||||||
DOI: | 10.1136/jech-2013-203646 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||||||
Grant number: | (GR/S29874/01) | ||||||||
Adapted As: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |