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Membrane composition variation and underdamped mechanics near transmembrane proteins and coats
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Rautu, S. Alex, Rowlands, G. (George) and Turner, Matthew S. (2015) Membrane composition variation and underdamped mechanics near transmembrane proteins and coats. Physical Review Letters, 114 (9). 098101. doi:10.1103/PhysRevLett.114.098101 ISSN 0031-9007.
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Official URL: http://dx.doi.org/10.1103/PhysRevLett.114.098101
Abstract
We study the effect of transmembrane proteins on the shape, composition, and thermodynamic stability of the surrounding membrane. When the coupling between membrane composition and curvature is strong enough, the nearby membrane composition and shape both undergo a transition from overdamped to underdamped spatial variation, well before the membrane becomes unstable in the bulk. This transition is associated with a change in the sign of the thermodynamic energy and, hence, favors the early stages of coat assembly necessary for vesiculation (budding) and may suppress the activity of mechanosensitive membrane channels and transporters. Our results suggest an approach to obtain physical parameters of the membrane that are otherwise difficult to measure.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||
Journal or Publication Title: | Physical Review Letters | ||||||
Publisher: | American Physical Society | ||||||
ISSN: | 0031-9007 | ||||||
Official Date: | 2 March 2015 | ||||||
Dates: |
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Volume: | 114 | ||||||
Number: | 9 | ||||||
Article Number: | 098101 | ||||||
DOI: | 10.1103/PhysRevLett.114.098101 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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