The Library
Non–high-density lipoprotein cholesterol and other lipid indices vs elevated glucose risk in Arab adolescents
Tools
Tools
Tools
Al-Daghri, Nasser M., Aljohani, Naji J., Al-Attas, Omar S., Al-Saleh, Yousef, Wani, Kaiser, Alnaami, Abdullah M., Alfawaz, Hanan, Al-Ajlan, Abdulrahman S.M., Kumar, Sudhesh, Chrousos, George P. and Alokail, Majed S. (2015) Non–high-density lipoprotein cholesterol and other lipid indices vs elevated glucose risk in Arab adolescents. Journal of Clinical Lipidology, 9 (1). pp. 35-41. doi:10.1016/j.jacl.2014.11.001
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1016/j.jacl.2014.11.001
Abstract
Background
Non–high-density lipoprotein cholesterol (non–HDL-C) has been identified as a significant predictor of various cardiovascular events in adults. Limited studies have been conducted in the pediatric population with diverse results, depending on ethnic origin. None has been conducted in the Arabic adolescent population so far; this study aims to fill this gap.
Methods
In this cross-sectional study, 1690 Saudi school adolescents (968 boys [mean age 14.8 ± 1.7] and 722 girls [mean age 14.6 ± 1.7]) were recruited. Anthropometrics were obtained. Fasting blood glucose and lipid profiles were quantified routinely. Non–HDL-C was calculated and screening was done for dyslipidemia using cutoffs obtained from the cohort and elevated fasting glucose.
Results
Using the 90th percentile cutoff obtained, the overall prevalence of high non–HDL-C (≥4.26 mmol/L) was 10.1%. Prevalence was slightly higher in girls (10.5%) than boys (9.9%). Non–HDL-C was similar to other lipids in terms of significant associations with anthropometric measures and glucose in both boys and girls. Elevated triglycerides was most predictive of elevated glucose in both girls (odds ratio 2.41; confidence interval 1.43–4.08; P = .001) and boys (odds ratio 2.61; confidence interval 1.70–4.0); P < .001).
Conclusion
Non–HDL-C appears to be gender-specific and is cardiometabolically more associated with Saudi boys, despite higher levels in girls. It is inferior compared with triglycerides in assessing elevated glucose risk. Further investigations may provide a more definite value for non–HDL-C use as a biomarker in assessing cardiometabolic risk in the Arab adolescent population
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
||||||||
| Journal or Publication Title: | Journal of Clinical Lipidology | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 19332874 | ||||||||
| Official Date: | January 2015 | ||||||||
| Dates: |
|
||||||||
| Volume: | 9 | ||||||||
| Number: | 1 | ||||||||
| Page Range: | pp. 35-41 | ||||||||
| DOI: | 10.1016/j.jacl.2014.11.001 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Adapted As: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
