Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Comparing multidrug-resistant tuberculosis patient costs under molecular diagnostic algorithms in South Africa

Tools
- Tools
+ Tools

du Toit, E., Squire, S. B., Dunbar, R., Machekano, R., Madan, Jason, Beyers, N. and Naidoo, P. (2015) Comparing multidrug-resistant tuberculosis patient costs under molecular diagnostic algorithms in South Africa. The international journal of tuberculosis and lung disease, 19 (8). pp. 960-968. doi:10.5588/ijtld.14.0703

[img] PDF
WRAP_wms_clinical_trials-110117-mdr_tb_patient_costs_20150213_r1.pdf - Accepted Version - Requires a PDF viewer.

Download (1160Kb)
Official URL: http://dx.doi.org/10.5588/ijtld.14.0703

Request Changes to record.

Abstract

SETTING: Ten primary health care facilities in Cape Town, South Africa, 2010–2013.

OBJECTIVE: A comparison of costs incurred by patients in GenoType® MDRTBplus line-probe assay (LPA) and Xpert® MTB/RIF-based diagnostic algorithms from symptom onset until treatment initiation for multidrug-resistant tuberculosis (MDR-TB).

METHODS: Eligible patients identified from laboratory and facility records were interviewed 3–6 months after treatment initiation and a cost questionnaire completed. Direct and indirect costs, individual and household income, loss of individual income and change in household income were recorded in local currency, adjusted to 2013 costs and converted to $US.

RESULTS: Median number of visits to initiation of MDR-TB treatment was reduced from 20 to 7 (P < 0.001) and median costs fell from US$68.1 to US$38.3 (P = 0.004) in the Xpert group. From symptom onset to being interviewed, the proportion of unemployed increased from 39% to 73% in the LPA group (P < 0.001) and from 53% to 89% in the Xpert group (P < 0.001). Median household income decreased by 16% in the LPA group and by 13% in the Xpert group.

CONCLUSION: The introduction of an Xpert-based algorithm brought relief by reducing the costs incurred by patients, but loss of employment and income persist. Patients require support to mitigate this impact.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Tuberculosis -- Diagnosis -- Cost effectiveness, Tuberculosis -- Diagnosis -- Cape Town (South Africa), Tuberculosis -- Diagnosis -- Interviews
Journal or Publication Title: The international journal of tuberculosis and lung disease
Publisher: International Union against Tuberculosis and Lung Disease,Union Internationale contre la Tuberculose et les Maladies Respiratoires
ISSN: 1815-7920
Official Date: 2015
Dates:
DateEvent
2015Published
18 March 2015Accepted
16 September 2014Submitted
Volume: 19
Number: 8
Page Range: pp. 960-968
DOI: 10.5588/ijtld.14.0703
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: United States. Agency for International Development (USAID)
Grant number: TREAT TB – Agreement No. GHN -A-00-08-00004-00

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us