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Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle

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Lee, Kian-Yong, Esmaeili, Behrooz, Zealley, Ben and Mishima, Masanori (2015) Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle. Nature Communications, 6 . 7290. doi:10.1038/ncomms8290

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Official URL: http://dx.doi.org/10.1038/ncomms8290

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Abstract

During animal cell division, the central spindle, an anti-parallel microtubule bundle structure formed between segregating chromosomes during anaphase, cooperates with astral microtubules to position the cleavage furrow. Because the central spindle is the only structure linking the two halves of the mitotic spindle, it is under mechanical tension from dynein-generated cortical pulling forces, which determine spindle positioning and drive chromosome segregation through spindle elongation. The central spindle should be flexible enough for efficient chromosome segregation while maintaining its structural integrity for reliable cytokinesis. How the cell balances these potentially conflicting requirements is poorly understood. Here, we demonstrate that the central spindle in C. elegans embryos has a resilient mechanism for recovery from perturbations by excess tension derived from cortical pulling forces. This mechanism involves the direct interaction of two different types of conserved microtubule bundlers that are crucial for central spindle formation, PRC1 and centralspindlin.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Spindle (Cell division), Microtubules, Chromosome replication, Cytokinesis
Journal or Publication Title: Nature Communications
Publisher: Nature Publishing Group
ISSN: 2041-1723
Official Date: 19 June 2015
Dates:
DateEvent
19 June 2015Available
26 April 2015Accepted
30 October 2014Submitted
Volume: 6
Article Number: 7290
DOI: 10.1038/ncomms8290
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Cancer Research UK (CRUK), Wellcome Trust (London, England), University of Cambridge. Commonwealth Trust
Grant number: C6946/A14492, C19769/A8024, C19769/A6356 and A11985 (CRUK), 092096 (Wellcome Trust)

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