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Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle
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Lee, Kian-Yong, Esmaeili, Behrooz, Zealley, Ben and Mishima, Masanori (2015) Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle. Nature Communications, 6 . 7290. doi:10.1038/ncomms8290
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Official URL: http://dx.doi.org/10.1038/ncomms8290
Abstract
During animal cell division, the central spindle, an anti-parallel microtubule bundle structure formed between segregating chromosomes during anaphase, cooperates with astral microtubules to position the cleavage furrow. Because the central spindle is the only structure linking the two halves of the mitotic spindle, it is under mechanical tension from dynein-generated cortical pulling forces, which determine spindle positioning and drive chromosome segregation through spindle elongation. The central spindle should be flexible enough for efficient chromosome segregation while maintaining its structural integrity for reliable cytokinesis. How the cell balances these potentially conflicting requirements is poorly understood. Here, we demonstrate that the central spindle in C. elegans embryos has a resilient mechanism for recovery from perturbations by excess tension derived from cortical pulling forces. This mechanism involves the direct interaction of two different types of conserved microtubule bundlers that are crucial for central spindle formation, PRC1 and centralspindlin.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history | ||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Spindle (Cell division), Microtubules, Chromosome replication, Cytokinesis | ||||||||
| Journal or Publication Title: | Nature Communications | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 2041-1723 | ||||||||
| Official Date: | 19 June 2015 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 16 January 2017 | ||||||||
| Volume: | 6 | ||||||||
| Article Number: | 7290 | ||||||||
| DOI: | 10.1038/ncomms8290 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Cancer Research UK (CRUK), Wellcome Trust (London, England), University of Cambridge. Commonwealth Trust | ||||||||
| Grant number: | C6946/A14492, C19769/A8024, C19769/A6356 and A11985 (CRUK), 092096 (Wellcome Trust) |
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