Foo, Mathias, Kim, Jongrae, Sawlekar, Rucha and Bates, Declan (2017) Design of an embedded inverse-feedforward biomolecular tracking controller for enzymatic reaction processes. Computers & Chemical Engineering, 99 . pp. 145-157. doi:10.1016/j.compchemeng.2017.01.027

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Abstract

Feedback control is widely used in chemical engineering to improve the performance and robustness of chemical processes. Feedback controllers require a ‘subtractor’ that is able to compute the error between the process output and the reference signal. In the case of embedded biomolecular control circuits, subtractors designed using standard chemical reaction network theory can only realise one-sided subtraction, rendering standard controller design approaches inadequate. Here, we show how a biomolecular controller that allows tracking of required changes in the outputs of enzymatic reaction processes can be designed and implemented within the framework of chemical reaction network theory. The controller architecture employs an inversion-based feedforward controller that compensates for the limitations of the one-sided subtractor that generates the error signals for a feedback controller. The proposed approach requires significantly fewer chemical reactions to implement than alternative designs, and should have wide applicability throughout the fields of synthetic biology and biological engineering.

Item Type:	Journal Article
Subjects:	T Technology > TP Chemical technology
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Feedforward control systems, Chemical engineering, Enzymes, Bioengineering, Process control, Synthetic biology
Journal or Publication Title:	Computers & Chemical Engineering
Publisher:	Pergamon
ISSN:	0098-1354
Official Date:	6 April 2017
Dates:	Date Event 6 April 2017 Published 17 January 2017 Available 16 January 2017 Accepted 14 October 2016 Submitted
Volume:	99
Page Range:	pp. 145-157
DOI:	10.1016/j.compchemeng.2017.01.027
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), University of Warwick. Department of Engineering
Grant number:	BB/M017982/1 (BBSRC)

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