The Library
BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI : a case-control study
Tools
Tools
Tools
Louwers, Yvonne V., Rayner, Nigel W., Herrera, Blanca M., Stolk, Lisette, Groves, Christopher J., Barber, T. M., Uitterlinden, Andre G., Franks, Stephen, Laven, Joop S. E. and McCarthy, Mark I. (2014) BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI : a case-control study. PLoS One, 9 (1). e87335. doi:10.1371/journal.pone.0087335
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1371/journal.pone.0087335
Abstract
Introduction:
Polycystic Ovary Syndrome (PCOS) has a strong genetic background and the majority of patients with PCOS have elevated BMI levels. The aim of this study was to determine to which extent BMI-increasing alleles contribute to risk of PCOS when contemporaneous BMI is taken into consideration.
Methods:
Patients with PCOS and controls were recruited from the United Kingdom (563 cases and 791 controls) and The Netherlands (510 cases and 2720 controls). Cases and controls were of similar BMI. SNPs mapping to 12 BMI-associated loci which have been extensively replicated across different ethnicities, i.e., BDNF, FAIM2, ETV5, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18, were studied in association with PCOS within each cohort using the additive genetic model followed by a combined analysis. A genetic allelic count risk score model was used to determine the risk of PCOS for individuals carrying increasing numbers of BMI-increasing alleles.
Results:
None of the genetic variants, including FTO and MC4R, was associated with PCOS independently of BMI in the meta-analysis. Moreover, no differences were observed between cases and controls in the number of BMI-risk alleles present and no overall trend across the risk score groups was observed.
Conclusion:
In this combined analysis of over 4,000 BMI-matched individuals from the United Kingdom and the Netherlands, we observed no association of BMI risk alleles with PCOS independent of BMI.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
||||||||
| Journal or Publication Title: | PLoS One | ||||||||
| Publisher: | Public Library of Science | ||||||||
| ISSN: | 1932-6203 | ||||||||
| Official Date: | 31 January 2014 | ||||||||
| Dates: |
|
||||||||
| Volume: | 9 | ||||||||
| Number: | 1 | ||||||||
| Article Number: | e87335 | ||||||||
| DOI: | 10.1371/journal.pone.0087335 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
