UNSPECIFIED. (2004) Nitric oxide inhibits NMDA currents in a subpopulation of substantia gelatinosa neurons of the adult rat spinal cord. NEUROSCIENCE LETTERS, 359 (3). pp. 180-184. ISSN 0304-3940

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Abstract

In the present study, the actions of nitric oxide (NO) on NMDA mediated excitatory neurotransmission in substantia gelatinosa (SG) neurons of the adult rat spinal cord were investigated. Bath application of the NO donor sodium-nitroso-N-acetylpenicillamine (SNAP) reversibly inhibited NMDA receptor mediated excitatory postsynaptic currents evoked by electrical stimulation of the dorsal root. These effects of SNAP were prevented by pre-incubation with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy PTIO) or the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one, and were mimicked by the membrane permeable cGMP analogue dibutyryl cGMP. Finally, these effects were shown to be mediated at a postsynaptic level using acutely applied exogenous NMDA. In conclusion, we demonstrate for the first time the inhibition of NMDA mediated excitatory neurotransmission by NO in spinal cord SG neurons, an action mediated at least in part via the activation of guanylate cyclase. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Journal or Publication Title:	NEUROSCIENCE LETTERS
Publisher:	ELSEVIER SCI IRELAND LTD
ISSN:	0304-3940
Date:	15 April 2004
Volume:	359
Number:	3
Number of Pages:	5
Page Range:	pp. 180-184
Identification Number:	10.1016/j.neulet.2004.01.057
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/8518

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