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Glycation- and/or Polyol pathway-inducing complications
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Rabbani, Naila and Thornalley, Paul J. (2014) Glycation- and/or Polyol pathway-inducing complications. In: Reference Module in Biomedical Sciences. Elsevier . ISBN 9780128012383
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Official URL: http://dx.doi.org/10.1016/B978-0-12-801238-3.03829...
Abstract
Glycation of proteins by glucose forms fructosamine residues. Glycated hemoglobin “A1C” thereby formed is an indicator of glycemic control in diabetes and a marker for diagnosis of diabetes and impaired glucose tolerance. Advanced glycation endproducts (AGEs) are formed by the degradation of fructosamine and glycation by reactive dicarbonyl metabolites such as methylglyoxal. Chemically stable AGEs in skin collagen are risk markers of diabetic microvascular complications. Methylglyoxal forms major protein and nucleotide AGEs, hydroimidazolone MG-H1 and imidazopurinone MGdG, and is a critical mediator of vascular complications of diabetes. It is metabolised by glyoxalase 1 and inducers of glyoxalase 1 expression are in development for novel therapy. The polyol pathway is a two-step metabolic pathway that converts glucose to fructose via sorbitol where the first step is catalysed by aldose reductase. Aldose reductase inhibitors may suppress the development of microvascular complication of diabetes.
Item Type: | Book Item | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
Publisher: | Elsevier | ||||||
ISBN: | 9780128012383 | ||||||
Book Title: | Reference Module in Biomedical Sciences | ||||||
Official Date: | 2014 | ||||||
Dates: |
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DOI: | 10.1016/B978-0-12-801238-3.03829-0 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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