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Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose
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Joubert, Fanny, Yeo, R. Paul, Sharples, Gary J., Musa, Osama M., Hodgson, David R. W. and Cameron, Neil R. (2015) Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose. Biomacromolecules, 16 (12). pp. 3970-3979. doi:10.1021/acs.biomac.5b01300 ISSN 1525-7797.
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Official URL: http://dx.doi.org/10.1021/acs.biomac.5b01300
Abstract
Poly(ionic liquid)s (P(IL)s) of different degrees of polymerization (10, 50, and 100) were prepared via RAFT polymerization using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ∼80% and a ĐM of 1.5 for P(IL)100. Subsequently, P(IL) chains were coupled to 15N-labeled azido-functionalized hydroxyethyl cellulose (HEC), forming graft copolymers of HEC with different chain length and graft densities, which were characterized using (13C and 15N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against Escherichia coli and Staphylococcus aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)10 on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example, in paint formulation.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||||
Library of Congress Subject Headings (LCSH): | Antiseptics , Antitubercular agents, Escherichia coli , Staphylococcus aureus, Copolymers, Polymerization | ||||||||||
Journal or Publication Title: | Biomacromolecules | ||||||||||
Publisher: | American Chemical Society | ||||||||||
ISSN: | 1525-7797 | ||||||||||
Official Date: | 14 December 2015 | ||||||||||
Dates: |
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Volume: | 16 | ||||||||||
Number: | 12 | ||||||||||
Page Range: | pp. 3970-3979 | ||||||||||
DOI: | 10.1021/acs.biomac.5b01300 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 19 January 2017 | ||||||||||
Date of first compliant Open Access: | 19 January 2017 | ||||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Ashland (Firm) |
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