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Novel actin filaments from Bacillus thuringiensisform nanotubules for plasmid DNA segregation
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Jiang, Shimin, Narita, Akihiro, Popp, David, Ghoshdastider, Umesh, Lee, Lin Jie, Srinivasan, Ramanujam, Balasubramanian, Mohan K., Oda, Toshiro, Koh, Fujiet, Larsson, Mårten and Robinson, Robert C. (2016) Novel actin filaments from Bacillus thuringiensisform nanotubules for plasmid DNA segregation. Proceedings of the National Academy of Sciences of the United States of America, 113 (9). E1200-E1205. doi:10.1073/pnas.1600129113 ISSN 0027-8424.
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Official URL: http://dx.doi.org/10.1073/pnas.1600129113
Abstract
Actins and tubulins have dedicated functions that vary between eukaryotes and prokaryotes. During cell division, the prokaryotic contractile ring depends on the tubulin-like protein FtsZ, whereas this task relies on actin in eukaryotes. In contrast, microtubules orchestrate DNA segregation in eukaryotes, yet prokaryotic plasmid segregation often depends on actin-like proteins; this implies that actins and tubulins have somewhat interchangeable properties. Hence, we sought a bacterial filament that more closely resembles microtubules. Here, we report an actin from Bacillus thuringiensis that forms dynamic, antiparallel, two-stranded supercoiled filaments, which pair in the presence of a binding partner to form hollow cylinders. Thus, in this prokaryote, the actin fold has evolved to produce a filament system with comparable properties to the eukaryotic microtubule.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Proceedings of the National Academy of Sciences of the United States of America | ||||||||
Publisher: | National Academy of Sciences | ||||||||
ISSN: | 0027-8424 | ||||||||
Official Date: | 2016 | ||||||||
Dates: |
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Volume: | 113 | ||||||||
Number: | 9 | ||||||||
Page Range: | E1200-E1205 | ||||||||
DOI: | 10.1073/pnas.1600129113 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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