The Library
Brown adipose tissue : endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity
Tools
Tools
Tools
Reddy, Narendra Lakshmana, Tan, Bee K., Barber, T. M. and Randeva, Harpal S. (2014) Brown adipose tissue : endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity. BMC Obesity, 1 (1). doi:10.1186/s40608-014-0013-5
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1186/s40608-014-0013-5
Abstract
Introduction:
Recent observation of brown adipose tissue (BAT) being functional in adult humans provides a rationale for its stimulation to increase energy expenditure through ‘adaptive thermogenesis’ for an anti-obesity strategy. Many endocrine dysfunctions are associated with changes in metabolic rate that over time may result in changes in body weight. It is likely that human BAT plays a role in such processes.
Review:
In this brief review article, we explore the endocrine determinants of BAT activity, and discuss how these insights may provide a basis for future developments of novel therapeutic strategies for obesity management.
A review of electronic and print data comprising original and review articles retrieved from PubMed search up to December 2013 was conducted (Search terms: brown adipose tissue, brown fat, obesity, hormone). In addition, relevant references from the articles were screened for papers containing original data.
Conclusion:
There is promising data to suggest that targeting endocrine hormones for BAT modulation can yield a cellular bioenergetics answer for successful prevention and management of human obesity. Further understanding of the physiological link between various endocrine hormones and BAT is necessary for the development of new therapeutic options.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
||||||||
| Journal or Publication Title: | BMC Obesity | ||||||||
| Publisher: | BioMed Central Ltd. | ||||||||
| ISSN: | 2052-9538 | ||||||||
| Official Date: | 22 August 2014 | ||||||||
| Dates: |
|
||||||||
| Volume: | 1 | ||||||||
| Number: | 1 | ||||||||
| DOI: | 10.1186/s40608-014-0013-5 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
