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Polycystic ovary syndrome and obesity
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Barber, T. M., Dimitriadis, Georgios K. and Franks, S. (2016) Polycystic ovary syndrome and obesity. In: Ahmad, Shamim I. and Imam, Syed Khalid, (eds.) Obesity : a practical guide. Springer, pp. 199-210. ISBN 9783319198200
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Official URL: http://doi.org/10.1007/978-3-319-19821-7_15
Abstract
Polycystic Ovary Syndrome (PCOS) is a common condition in reproductive-age women. PCOS is characterized by both reproductive dysfunction and hyperandrogenemia. Importantly, PCOS is also associated with metabolic aberrations, including insulin resistance. There is a strong association between obesity and PCOS, based on epidemiology, aetiology and genetics studies. Increased adiposity worsens insulin resistance (which in turn results in compensatory hyperinsulinemia, with associated pleiotropic effects) and disrupts steroid metabolism, further enhancing androgenicity. Through these mechanisms, weight-gain unmasks PCOS in those women who are genetically predisposed. Conversely, even modest weight-loss of just 5 % body weight in obese women with PCOS often results in clinically meaningful improvements in reproductive, hyperandrogenic and metabolic dysfunction. Given inextricable interlinks between PCOS and obesity, novel therapies that promote weight-loss, including activation of brown adipose tissue, remain perhaps our most promising future therapeutic options for obese women with PCOS.
| Item Type: | Book Item | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
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| Publisher: | Springer | ||||
| ISBN: | 9783319198200 | ||||
| Book Title: | Obesity : a practical guide | ||||
| Editor: | Ahmad, Shamim I. and Imam, Syed Khalid | ||||
| Official Date: | 2016 | ||||
| Dates: |
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| Page Range: | pp. 199-210 | ||||
| DOI: | 10.1007/978-3-319-19821-7_15 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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