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Synthesis of star-branched poly(vinyl alcohol) and ice recrystallization inhibition activity
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Congdon, Thomas R., Notman, Rebecca and Gibson, Matthew I. (2017) Synthesis of star-branched poly(vinyl alcohol) and ice recrystallization inhibition activity. European Polymer Journal, 88 . pp. 320-327. doi:10.1016/j.eurpolymj.2017.01.039 ISSN 0014-3057.
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Official URL: https://doi.org/10.1016/j.eurpolymj.2017.01.039
Abstract
Antifreeze proteins are potent inhibitors of ice crystal growth (recrystallization), which is a highly desirable property for cryopreservation and other low temperature applications. It has
emerged that relatively simple polymers based on poly(vinyl alcohol) can mimic this activity, but the link between architecture and activity is not known. Here, a trifunctional xanthate was designed and synthesized to prepare star-branched poly(vinyl alcohols) by RAFT/Xanthate mediated polymerization, and their ice growth inhibition activity probed for the first time. The trifunctional agent design affords the formation of well-defined star polymers, with no evidence
of star-star linking, even at high conversions, and narrow molecular weight dispersity. It is observed that three-arm stars have identical activity to two-armed (i.e. linear) equivalents, suggesting that the total hydrodynamic size of the polymer (diameter three-arm ~ two-arm)
rather than total valence of the functional groups is the key descriptor of activity
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Antifreeze proteins, Ice crystals -- Growth, Polyvinyl alcohol, Polymers, Addition polymerization | ||||||||
| Journal or Publication Title: | European Polymer Journal | ||||||||
| Publisher: | Pergamon | ||||||||
| ISSN: | 0014-3057 | ||||||||
| Official Date: | March 2017 | ||||||||
| Dates: |
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| Volume: | 88 | ||||||||
| Page Range: | pp. 320-327 | ||||||||
| DOI: | 10.1016/j.eurpolymj.2017.01.039 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 30 January 2017 | ||||||||
| Date of first compliant Open Access: | 2 September 2018 | ||||||||
| Funder: | The Leverhulme Trust, European Research Council (ERC) CRYOMAT Project | ||||||||
| Grant number: | (RPG-144) ; 638661 | ||||||||
| Is Part Of: |
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