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Cardiolipin signaling mechanisms : collapse of asymmetry and oxidation
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Kagan, Valerian E., Tyurina, Yulia Y., Tyurin, Vladimir A., Mohammadyani, Dariush, Angeli, Jose Pedro Friedmann, Baranov, Sergei V., Klein-Seetharaman, Judith, Friedlander, Robert M., Mallampalli, Rama K., Conrad, Marcus and Bayir, Hülya (2015) Cardiolipin signaling mechanisms : collapse of asymmetry and oxidation. Antioxidants & Redox Signaling, 22 (18). pp. 1667-1680. doi:10.1089/ars.2014.6219
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Official URL: http://dx.doi.org/10.1089/ars.2014.6219
Abstract
Significance: An ancient anionic phospholipid, cardiolipin (CL), ubiquitously present in prokaryotic and eukaryotic membranes, is essential for several structural and functional purposes. Recent Advances: The emerging role of CLs in signaling has become the focus of many studies. Critical Issues: In this work, we describe two major pathways through which mitochondrial CLs may fulfill the signaling functions via utilization of their (i) asymmetric distribution across membranes and translocations, leading to the surface externalization and (ii) ability to undergo oxidation reactions to yield the signature products recognizable by the executionary machinery of cells. Future Directions: We present a concept that CLs and their oxidation/hydrolysis products constitute a rich communication language utilized by mitochondria of eukaryotic cells for diversified regulation of cell physiology and metabolism as well as for inter-cellular interactions.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Antioxidants & Redox Signaling | ||||
| Publisher: | Mary Ann Liebert, Inc. Publishers | ||||
| ISSN: | 1523-0864 | ||||
| Official Date: | June 2015 | ||||
| Dates: |
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| Volume: | 22 | ||||
| Number: | 18 | ||||
| Page Range: | pp. 1667-1680 | ||||
| DOI: | 10.1089/ars.2014.6219 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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