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Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate
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Yanamala, N., Kapralov, A. A., Djukic, M., Peterson, J., Mao, G., Klein-Seetharaman, J., Stoyanovsky, D. A., Stursa, J., Neuzil, J. and Kagan, V. E. (2014) Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate. Journal of Biological Chemistry, 289 (47). pp. 32488-32498. doi:10.1074/jbc.M114.601377
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Official URL: http://dx.doi.org/10.1074/jbc.M114.601377
Abstract
Background: An anionic phospholipid, cardiolipin, converts cytochrome c into a peroxidase.
Results: Anionic tocopherol derivatives, tocopherol succinate and tocopherol phosphate, similarly to cardiolipin, unfold cytpchrome c and stimulate its peroxidase activity.
Conclusion: Peroxidase activation of cytochrome c by tocopherol analogues is one of their pharmacological mechanisms.
Significance: Peroxidase activation of cytochrome c may induce apoptosis and contribute to anti-cancer properties of α-tocopherol succinate.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Biological Chemistry | ||||||
| Publisher: | American Society for Biochemistry and Molecular Biology | ||||||
| ISSN: | 0021-9258 | ||||||
| Official Date: | 2 October 2014 | ||||||
| Dates: |
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| Volume: | 289 | ||||||
| Number: | 47 | ||||||
| Page Range: | pp. 32488-32498 | ||||||
| DOI: | 10.1074/jbc.M114.601377 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
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