Morse, Robert P., Allingham, D. and Stocks, Nigel G. (2015) A phenomenological model of myelinated nerve with a dynamic threshold. Journal of Theoretical Biology, 382 . pp. 386-396. doi:10.1016/j.jtbi.2015.06.035

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Abstract

To evaluate coding strategies for cochlear implants a model of the human cochlear nerve is required. Nerve models based on voltage-clamp experiments, such as the Frankenhaeuser-Huxley model of myelinated nerve, can have over forty parameters and are not amenable for fitting to physiological data from a different animal or type of nerve. Phenomenological nerve models, such as leaky integrate-and-fire (LIF) models, have fewer parameters but have not been validated with a wide range of stimuli. In the absence of substantial cochlear nerve data, we have used data from a toad sciatic nerve for validation (50 Hz to 2 kHz with levels up to 20 dB above threshold). We show that the standard LIF model with fixed refractory properties and a single set of parameters cannot adequately predict the toad rate-level functions. Given the deficiency of this standard model, we have abstracted the dynamics of the sodium inactivation variable in the Frankenhaeuser-Huxley model to develop a phenomenological LIF model with a dynamic threshold. This nine-parameter model predicts the physiological rate-level functions much more accurately than the standard LIF model. Because of the low number of parameters, we expect to be able to optimize the model parameters so that the model is more appropriate for cochlear implant simulations.

Item Type:	Journal Article
Alternative Title:
Subjects:	Q Science > QP Physiology
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Human physiology., Cochlear implants., Nervous system -- Surgery., Neural conduction
Journal or Publication Title:	Journal of Theoretical Biology
Publisher:	Elsevier
ISSN:	0022-5193
Official Date:	7 October 2015
Dates:	Date Event 7 October 2015 Published 30 June 2015 Available 20 June 2015 Accepted 2 February 2015 Submitted
Volume:	382
Page Range:	pp. 386-396
DOI:	10.1016/j.jtbi.2015.06.035
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Medical Research Council (Great Britain) (MRC), Engineering and Physical Sciences Research Council (EPSRC)
Grant number:	MRC (grant G0001114) and EPSRC (grant GR/35650/01).

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