The Library
Microglia PACAP and glutamate : friends or foes in seizure-induced autonomic dysfunction and SUDEP?
Tools
Bhandare, Amol M., Kapoor, Komal, Farnham, Melissa M. J. and Pilowsky, Paul M. (2016) Microglia PACAP and glutamate : friends or foes in seizure-induced autonomic dysfunction and SUDEP? Respiratory Physiology & Neurobiology, 226 . pp. 39-50. ISSN 1569-9048.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: https://doi.org/10.1016/j.resp.2016.01.003
Abstract
Seizure-induced cardiorespiratory autonomic dysfunction is a major cause of sudden unexpected death in epilepsy (SUDEP), and the underlying mechanism is unclear. Seizures lead to increased synthesis, and release of glutamate, pituitary adenylate cyclase activating polypeptide (PACAP), and other neurotransmitters, and cause extensive activation of microglia at multiple regions in the brain including central autonomic cardiorespiratory brainstem nuclei. Glutamate contributes to neurodegeneration, and inflammation in epilepsy. PACAP has neuroprotective, and anti-inflammatory properties, whereas microglia are key players in inflammatory responses in CNS. Seizure-induced increase in PACAP is neuroprotective. PACAP produces neuroprotective effects acting on microglial PAC1 and VPAC1 receptors. Microglia also express glutamate transporters, and their expression can be increased by PACAP in response to harmful or stressful situations such as seizures. Here we discuss the mechanism of autonomic cardiorespiratory dysfunction in seizure, and the role of PACAP, glutamate and microglia in regulating cardiorespiratory brainstem neurons in their physiological state that could provide future therapeutic options for SUDEP.
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
Journal or Publication Title: | Respiratory Physiology & Neurobiology | ||||||||||
Publisher: | Elsevier BV | ||||||||||
ISSN: | 1569-9048 | ||||||||||
Official Date: | June 2016 | ||||||||||
Dates: |
|
||||||||||
Volume: | 226 | ||||||||||
Page Range: | pp. 39-50 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |