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Alerted microglia and the sympathetic nervous system : a novel form of microglia in the development of hypertension

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Kapoor, Komal, Bhandare, Amol M., Farnham, Melissa M. J. and Pilowsky, Paul M. (2016) Alerted microglia and the sympathetic nervous system : a novel form of microglia in the development of hypertension. Respiratory Physiology & Neurobiology, 226 . pp. 51-62.

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Official URL: http://dx.doi.org/10.1016/j.resp.2015.11.015

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Abstract

Microglia, commonly known as the tissue resident macrophages of the central nervous system (CNS), are ubiquitously expressed in the CNS. Microglia, in their resting, or surveilling, stage, play a critical role in the maintenance of normal neuronal physiology and homeostasis. On activation, microglia can acquire either a neurotoxic (M1) or a neuroprotective (M2) phenotype. Prior to development of the M1 or M2 phenotype, little was known about changes in microglial activity, when subjected to stimuli. It is postulated, that an inability of microglia to maintain neuronal physiology within a normal working range can contribute to the development of cardiovascular disorders (CVDs) such as hypertension, but clear evidence supporting this hypothesis is missing. Even though our understanding of microglial function in a state of CNS injury/inflammation is extensive, the literature concerning role of microglia in the healthy CNS, is limited. Involvement of microglia in the pathophysiology of CVDs, in a neuroprotective/neurotoxic manner, is a key area that requires further investigation.

Item Type: Journal Article
Divisions: Faculty of Science > Life Sciences (2010- )
Journal or Publication Title: Respiratory Physiology & Neurobiology
Publisher: Elsevier BV
ISSN: 1569-9048
Official Date: June 2016
Dates:
DateEvent
June 2016Published
28 November 2015Available
25 November 2015Accepted
16 September 2015Submitted
Volume: 226
Page Range: pp. 51-62
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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